MET antibody (Met Proto-Oncogene) (pTyr1349)

Details for Product anti-MET Antibody No. ABIN966570, Supplier: Log in to see
Antigen
  • AUTS9
  • HGFR
  • RCCP2
  • c-Met
  • AI838057
  • HGF
  • Par4
  • Hgfr
  • c-met
  • met proto-oncogene
  • met proto-oncogene (hepatocyte growth factor receptor)
  • MET
  • Met
Alternatives
anti-Human MET antibody for Immunofluorescence (fixed cells)
Epitope
pTyr1349
80
72
45
39
38
28
23
19
17
15
15
15
15
14
9
9
8
6
6
6
6
5
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
683
284
218
19
15
8
6
6
5
3
3
3
3
2
1
1
1
Host
Rabbit
435
253
5
4
4
1
Conjugate
This MET antibody is un-conjugated
23
22
22
19
12
12
11
10
7
7
7
7
7
6
6
5
5
5
5
5
5
5
5
5
5
5
5
5
4
1
1
Application
Immunohistochemistry (IHC)
476
198
127
118
94
79
65
36
23
19
13
10
7
3
3
2
1
1
1
1
1
1
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Met around the phosphorylation site of tyrosine 1349 (E-H-YP-V-H).
Specificity Met (phospho-Tyr1349) antibody detects endogenous levels of Met only when phosphorylated at tyrosine 1349.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Met (MET Antibody Abstract)
Pathways RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
Application Notes WB: 1:500~1:1000
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Schiering, Knapp, Marconi, Flocco, Cui, Perego, Rusconi, Cristiani: "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 22, pp. 12654-9, 2003 (PubMed).

Fan, Ma, Gao, Yuan, Meng, Goldberg, Rosen: "The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair." in: Molecular and cellular biology, Vol. 21, Issue 15, pp. 4968-84, 2001 (PubMed).

Plopper, McNamee, Dike, Bojanowski, Ingber: "Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex." in: Molecular biology of the cell, Vol. 6, Issue 10, pp. 1349-65, 1996 (PubMed).

Ponzetto, Bardelli, Maina, Longati, Panayotou, Dhand, Waterfield, Comoglio: "A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor." in: Molecular and cellular biology, Vol. 13, Issue 8, pp. 4600-8, 1993 (PubMed).