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Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 74-88), (C-Term) antibody

Details for Product No. ABIN966576, Supplier: Log in to see
Antigen
  • CCL4
  • K203
  • CCL4L2
  • Mip1-b
  • Scya4
  • ACT2
  • AT744.1
  • G-26
  • HC21
  • LAG-1
  • LAG1
  • MIP-1-beta
  • MIP1B
  • MIP1B1
  • SCYA2
  • SCYA4
  • Act-2
  • MIP-1B
  • Mip1b
  • MIP-1beta
  • MIP-1BETA
  • MIP1b
  • SCY4A
  • AT744.2
  • CCL4L
  • SCYA4L
Epitope
C-Term, AA 74-88
23
14
13
13
10
5
4
4
3
3
2
2
1
1
1
Reactivity
Mouse (Murine)
128
62
36
6
5
5
2
1
1
1
Host
172
13
4
3
3
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
24
13
10
5
4
3
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
150
119
30
22
19
12
10
10
9
8
5
4
3
3
2
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of mouse MIP1b (74-88 aa), identical to the related mouse and rat sequence.
Alternative Name MIP-1b (CCL4 Antibody Abstract)
Background Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. Modi et al. (1991) assigned the SCYA4 gene to a slightly more distal location than had Irving et al. (1990): 17q21-q23 rather than 17q11-q21.
Pathways
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Bystry, Aluvihare, Welch et al.: "B cells and professional APCs recruit regulatory T cells via CCL4." in: Nature immunology, Vol. 2, Issue 12, pp. 1126-32, 2001 (PubMed).

Kamin-Lewis, Abdelwahab, Trang et al.: "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9283-8, 2001 (PubMed).

Cocchi, DeVico, Garzino-Demo et al.: "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells." in: Science (New York, N.Y.), Vol. 270, Issue 5243, pp. 1811-5, 1996 (PubMed).

Irving, Zipfel, Balke et al.: "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q." in: Nucleic acids research, Vol. 18, Issue 11, pp. 3261-70, 1990 (PubMed).