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Chemokine (C-C Motif) Ligand 4 (CCL4) (C-Term,AA 74-88) antibody
|Synonyms||ACT2, G-26, LAG1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MGC104418, MGC126025, MGC126026, MIP-1-beta, CCL4, K203, CCL4L2, Scya4, Mip1-b, MIP-1beta, MIP1b, SCY4A, MIP-1BETA|
Alternatives Western Blotting (WB)
|4 references available|
|Price||316.25 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminal of mouse MIP1b (74-88 aa), identical to the related mouse and rat sequence.|
|Reconstitution||0.2ml of distilled water will yield a concentration of 500µg/ml.|
|Description||Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. Modi et al. (1991) assigned the SCYA4 gene to a slightly more distal location than had Irving et al. (1990): 17q21-q23 rather than 17q11-q21.|
|Buffer||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4|
|Preservative||0.05mg Thiomersal, 0.05mg NaN3.|
|Storage||At -20°C for one year. After reconstitution, at 4°C for one month.|
|Restrictions||For Research Use only|
Irving, Zipfel, Balke et al.: "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q." in: Nucleic acids research, Vol. 18, Issue 11, pp. 3261-70, 1990 (PubMed).
Cocchi, DeVico, Garzino-Demo et al.: "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells." in: Science (New York, N.Y.), Vol. 270, Issue 5243, pp. 1811-5, 1996 (PubMed).
Kamin-Lewis, Abdelwahab, Trang et al.: "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9283-8, 2001 (PubMed).
Bystry, Aluvihare, Welch et al.: "B cells and professional APCs recruit regulatory T cells via CCL4." in: Nature immunology, Vol. 2, Issue 12, pp. 1126-32, 2001 (PubMed).