Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) (pSer189) antibody

Details for Product No. ABIN966578
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Antigen
Synonyms Mkk3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, AW212142, Prkmk3, mMKK3b, map2k3, zMKK3
Epitope
pSer189
(39), (22), (12), (7), (7), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(194), (103), (95), (26), (25), (15), (12), (12), (2), (1), (1)
Host
Rabbit
(158), (37)
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(163), (68), (50), (45), (40), (30), (12), (9), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN966578
385.00 $
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human MKK3 around the phosphorylation site of serine 189 (V-D-SP-V-A).
Specificity MKK3 (phospho-Ser189) Antibody detects endogenous levels of MKK3 only when phosphorylated at serine189.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name MKK3
Research Area Kinases/Phosphatases
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Raingeaud, Whitmarsh, Barrett et al.: "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 1247-55, 1996 (PubMed).

Wang, Chen, Liao et al.: "Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3389-403, 2002 (PubMed).

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