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MYC (pThr58) antibody

Details for Product No. ABIN966616, Supplier: Log in to see
Antigen
Epitope
pThr58
32
27
27
14
14
12
12
11
5
4
4
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
249
108
97
6
2
1
1
1
1
1
1
Host
Rabbit
200
47
2
1
Conjugate
Un-conjugated
6
6
6
6
6
6
4
Application
Immunohistochemistry (IHC)
183
113
95
45
18
18
17
7
6
6
6
6
4
3
2
1
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Myc around the phosphorylation site of threonine 58 (L-P-TP-P-P).
Specificity Myc (phospho-Thr58) antibody detects endogenous levels of Myc only when phosphorylated at threonine 58.
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Abé: "Hormonal control of meiosis initiation in the testis from Japanese newt, Cynops pyrrhogaster." in: Zoological science, Vol. 21, Issue 7, pp. 691-704, 2004 (PubMed).

Background publications Jin, Gao, Flagg, Deng: "Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 40209-19, 2004 (PubMed).

Welcker, Orian, Jin, Grim, Grim, Harper, Eisenman, Clurman: "The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 24, pp. 9085-90, 2004 (PubMed).

Baudino, Cleveland: "The Max network gone mad." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 691-702, 2001 (PubMed).