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Nuclear Receptor Co-Repressor 1 (NCOR1) (AA 1-192) antibody

Details for Product No. ABIN966640, Supplier: Login to see
Antigen
  • ncor
  • zgc:56355
  • 5730405M06Rik
  • A230020K14Rik
  • N-CoR
  • RIP13
  • Rxrip13
  • mKIAA1047
  • N-CoR1
  • TRAC1
  • hN-CoR
Epitope
AA 1-192
24
15
14
7
3
3
2
1
1
1
1
1
1
1
1
Reactivity
Human
93
36
20
3
Host
Mouse
80
11
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
62
57
51
11
10
9
3
3
2
1
1
1
Supplier
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Immunogen Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.
Clone 7A7A9
Isotype IgG1
Purification Ascitic fluid
Alternative Name NCOR1 (NCOR1 Antibody Abstract)
Background NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
Synonyms: N-CoR, TRAC1, hN-CoR
Gene ID 9611
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Atsumi, Tomita, Kiyoi et al.: "Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo." in: Biochemical and biophysical research communications, Vol. 345, Issue 4, pp. 1471-80, 2006 (PubMed).

Zhang, Yoon, Wong: "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)." in: Molecular and cellular biology, Vol. 25, Issue 15, pp. 6404-14, 2005 (PubMed).