Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (C-Term) antibody

Antigen: Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2)

Synonyms: p50, KBF1, p105, EBP-1, MGC54151, NFKB-p50, NF-kappaB, NFKB-p105, NF-kappa-B, DKFZp686C01211, p52, LYT10, LYT-10, NF-kB, NF-KB1, NFKB1, kbf1, ebp-1, MGC86262, nfkb-p50, nf-kappaB, nfkb-p105, nf-kappa-b, NFKB2, MGC179374

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966669

Additional Information

Alternative name: NFKB2

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human NFKB2 (Nuclear factor NF-kappa-B p100 subunit)

Description: NFKB2 (Nuclear factor NF-kappa-B p100 subunit) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
Synonyms: LYT10(Lymphocyte translocation chromosome 10)

Synonyms: p50, KBF1, p105, EBP-1, MGC54151, NFKB-p50, NF-kappaB, NFKB-p105, NF-kappa-B, DKFZp686C01211, p52, LYT10, LYT-10, NF-kB, NF-KB1, NFKB1, kbf1, ebp-1, MGC86262, nfkb-p50, nf-kappaB, nfkb-p105, nf-kappa-b, NFKB2, MGC179374

Application Details

Restrictions: For Research Use only

Publications

Product: Bours, Burd, Brown et al.: "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site." in: Molecular and cellular biology, Vol. 12, Issue 2, pp. 685-95, 1992 (PubMed).

Schmid, Perkins, Duckett et al.: "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65." in: Nature, Vol. 352, Issue 6337, pp. 733-6, 1991 (PubMed).

Dobrzanski, Ryseck, Bravo: "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." in: The EMBO journal, Vol. 13, Issue 19, pp. 4608-16, 1994 (PubMed).

Beg, Baldwin: "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor." in: Oncogene, Vol. 9, Issue 5, pp. 1487-92, 1994 (PubMed).

Potter, Larson, Eckes et al.: "Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18882-90, 1993 (PubMed).

Bours, Franzoso, Azarenko et al.: "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers." in: Cell, Vol. 72, Issue 5, pp. 729-39, 1993 (PubMed).

Li, Nabel: "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, 1997 (PubMed).