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Lipocalin 2 (LCN2) (AA 38-53), (N-Term) antibody

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Antigen
  • 24p3
  • AW212229
  • LCN2
  • MSFI
  • NGAL
  • Sip24
Epitope
N-Term, AA 38-53
22
17
13
12
12
9
7
5
4
4
3
1
1
Reactivity
Rat (Rattus)
340
119
93
66
37
1
1
1
Host
305
175
39
35
5
2
Clonality
Polyclonal
Conjugate
Un-conjugated
64
35
29
14
13
13
12
12
12
12
12
12
12
12
12
12
12
12
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
432
399
88
80
26
25
21
11
9
5
5
4
2
1
1
1
1
1
1
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of rat NGAL (38-53 aa), identical to the related mouse and rat sequence.
Alternative Name NGAL (LCN2 Antibody Abstract)
Background Europhile gelatinase-associated lipocalin (NGAL) is a protein that in humans is encoded by the LCN2 gene. The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor.
Application Notes WB: The detection limit for NGAL is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Matloubian, Lo, Cinamon, Lesneski, Xu, Brinkmann, Allende, Proia, Cyster: "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1." in: Nature, Vol. 427, Issue 6972, pp. 355-60, 2004

Flo, Smith, Sato, Rodriguez, Holmes, Strong, Akira, Aderem: "Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron." in: Nature, Vol. 432, Issue 7019, pp. 917-21, 2004

Cowland, Borregaard: "Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans." in: Genomics, Vol. 45, Issue 1, pp. 17-23, 1997

Chan, Simon-Chazottes, Mattei, Guenet, Salier: "Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2." in: Genomics, Vol. 23, Issue 1, pp. 145-50, 1995

Begley, Robb, Rockman, Visvader, Bockamp, Chan, Green: "Structure of the gene encoding the murine SCL protein." in: Gene, Vol. 138, Issue 1-2, pp. 93-9, 1994

Kjeldsen, Johnsen, Sengeløv, Borregaard: "Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase." in: The Journal of biological chemistry, Vol. 268, Issue 14, pp. 10425-32, 1993