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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Lipocalin 2 (LCN2) (N-Term,AA 38-53) antibody
|Synonyms||24p3, MSFI, NGAL, LCN2, Sip24, AW212229|
Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|6 references available|
|Price||316.25 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminal of rat NGAL (38-53 aa), identical to the related mouse and rat sequence.|
|Reconstitution||0.2ml of distilled water will yield a concentration of 500µg/ml.|
|Description||Europhile gelatinase-associated lipocalin (NGAL) is a protein that in humans is encoded by the LCN2 gene. The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor.|
|Application Notes||WB: The detection limit for NGAL is approximately 2.5ng/lane under non-reducing and reducing conditions.|
|Buffer||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4|
|Preservative||0.05mg Thiomersal, 0.05mg NaN3.|
|Storage||At -20°C for one year. After reconstitution, at 4°C for one month.|
|Restrictions||For Research Use only|
Kjeldsen, Johnsen, Sengeløv et al.: "Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase." in: The Journal of biological chemistry, Vol. 268, Issue 14, pp. 10425-32, 1993 (PubMed).
Chan, Simon-Chazottes, Mattei et al.: "Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2." in: Genomics, Vol. 23, Issue 1, pp. 145-50, 1995 (PubMed).
Begley, Robb, Rockman et al.: "Structure of the gene encoding the murine SCL protein." in: Gene, Vol. 138, Issue 1-2, pp. 93-9, 1994 (PubMed).
Cowland, Borregaard: "Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans." in: Genomics, Vol. 45, Issue 1, pp. 17-23, 1997 (PubMed).
Matloubian, Lo, Cinamon et al.: "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1." in: Nature, Vol. 427, Issue 6972, pp. 355-60, 2004 (PubMed).
Flo, Smith, Sato et al.: "Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron." in: Nature, Vol. 432, Issue 7019, pp. 917-21, 2004 (PubMed).
|Hosts||Rabbit (55), Mouse (16), Goat (10), Sheep (3), Rat (1)|
|Reactivities||Human (63), Mouse (Murine) (30), Rat (Rattus) (30), Dog (Canine) (21), Pig (Porcine) (19), Cow (Bovine) (18)|
|Applications||Western Blotting (WB) (55), ELISA (48), Immunofluorescence (IF) (19), Immunohistochemistry (IHC) (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunoassay (IA) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Dot Blot (Dot) (2), Immunoprecipitation (IP) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Paraformaldehyde) (IHC (pfa)) (1)|
|Conjugates||Biotin (9), FITC (5), HRP (4), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (3), N-Term (3), Internal Region (2), AA 21-198 (1)|