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Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) antibody

Details for Product No. ABIN966704
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Antigen
Synonyms npm4, npm, B23, NPM, NO38, B23NP, Npm, CG7917, CRP1, Crp1, Dmel\\CG7917, dNLP, dNLP-S, p22
Reactivity
Human, Monkey
(211), (116), (115), (50), (49), (42), (15), (7), (7), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(165), (63), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (7), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA
(186), (96), (65), (61), (59), (40), (37), (35), (18), (10), (3), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN966704
371.25 $
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Immunogen Purified recombinant fragment of human NPM expressed in E. Coli.
Clone 7H10B9
Isotype IgG1
Purification Ascitic fluid
Alternative Name Nucleophosmin
Background Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Synonyms: B23, NPM
Molecular Weight 33kDa
Gene ID 4869
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Morris, Kirstein, Valentine et al.: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).

Yoneda-Kato, Look, Kirstein et al.: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." in: Oncogene, Vol. 12, Issue 2, pp. 265-75, 1996 (PubMed).

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