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Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) antibody

Details for Product No. ABIN966704, Supplier: Log in to see
Antigen
  • npm4
  • npm
  • B23
  • NPM
  • NO38
  • B23NP
  • Npm
  • CG7917
  • CRP1
  • Crp1
  • Dmel\\CG7917
  • dNLP
  • dNLP-S
  • p22
Reactivity
Human, Monkey
228
110
106
9
7
7
7
7
3
2
1
1
1
1
Host
Mouse
175
62
16
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
9
6
3
3
3
3
3
3
3
3
2
2
2
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
204
104
77
60
55
31
17
15
13
7
4
3
3
Supplier
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Immunogen Purified recombinant fragment of human NPM expressed in E. Coli.
Clone 7H10B9
Isotype IgG1
Purification Ascitic fluid
Alternative Name Nucleophosmin (NPM1 Antibody Abstract)
Background Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Synonyms: B23, NPM
Molecular Weight 33kDa
Gene ID 4869
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Yoneda-Kato, Look, Kirstein et al.: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." in: Oncogene, Vol. 12, Issue 2, pp. 265-75, 1996 (PubMed).

Morris, Kirstein, Valentine et al.: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).

Background publications Bullrich, Morris, Hummel et al.: "Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas." in: Cancer research, Vol. 54, Issue 11, pp. 2873-7, 1994 (PubMed).