Mu Opioid Receptor 1 antibody (C-Term)

Catalog No. ABIN966719

Product Details anti-Mu Opioid Receptor 1 Antibody

Target: Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mu Opioid Receptor 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very Cterminal residues of human OPRM1(Mu-type opioid receptor)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-Mu Opioid Receptor 1 antibody (ABIN966719)

Xu, Xu, Hurd, Pasternak, Pan: "Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." in: Journal of neurochemistry, Vol. 108, Issue 4, pp. 962-72, (2009) (PubMed).

Pan, Xu, Yu, Xu, Pan, Pasternak: "Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." in: Neuroscience, Vol. 133, Issue 1, pp. 209-20, (2005) (PubMed).

Pan, Xu, Mahurter, Xu, Gilbert, Pasternak: "Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." in: Biochemical and biophysical research communications, Vol. 301, Issue 4, pp. 1057-61, (2003) (PubMed).

Uhl, Sora, Wang: "The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 7752-5, (1999) (PubMed).

Mestek, Hurley, Bye, Campbell, Chen, Tian, Liu, Schulman, Yu: "The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 3 Pt 2, pp. 2396-406, (1995) (PubMed).

Wang, Johnson, Persico, Hawkins, Griffin, Uhl: "Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." in: FEBS letters, Vol. 338, Issue 2, pp. 217-22, (1994) (PubMed).

Bare, Mansson, Yang: "Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." in: FEBS letters, Vol. 354, Issue 2, pp. 213-6, (1994) (PubMed).

Target Details for Mu Opioid Receptor 1

Target: Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))

Alternative Name: OPRM1 (OPRM1 Products)

Synonyms: LMOR antibody, M-OR-1 antibody, MOP antibody, MOR antibody, MOR1 antibody, OPRM antibody, MOP-R antibody, MOR-1 antibody, MOR-1O antibody, Oprm antibody, mor antibody, muOR antibody, MORA antibody, Oprrm1 antibody, or2 antibody, ZFOR2 antibody, OPRM1 antibody, opioid receptor mu 1 antibody, opioid receptor, mu 1 antibody, outer membrane protein OprM antibody, OPRM1 antibody, Oprm1 antibody, oprm1 antibody, oprM1 antibody

Background: OPRM1(Mu-type opioid receptor) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. OPRM1forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. OPRM1 interacts with RGSZ17 and RGSZ20. OPRM1 is a multi-pass membrane protein. The polymorphism Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. OPRM1(Mu-type opioid receptor) belongs to the G-protein coupled receptor 1 family.

Pathways: cAMP Metabolic Process, Synaptic Membrane