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Mu Opioid Receptor 1 antibody (Opioid Receptor, mu 1) (C-Term)

Details for Product anti-OPRM1 Antibody No. ABIN966719, Supplier: Log in to see
Antigen
  • or2
  • ZFOR2
  • OPRM1
  • Mor1
  • MORA
  • Oprm
  • Oprrm1
  • LMOR
  • M-OR-1
  • MOP
  • MOR
  • MOR1
  • OPRM
  • MOP-R
  • MOR-1
  • MOR-1O
  • mor
  • muOR
  • 6430411K18Rik
  • Mar
  • Mart1
  • Peg11
Alternatives
anti-Human Mu Opioid Receptor 1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
25
16
15
13
11
11
9
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
100
45
41
7
5
5
3
2
1
1
1
1
1
1
1
1
1
1
1
Host
Rabbit
100
4
3
Clonality
Polyclonal
Conjugate
This Mu Opioid Receptor 1 antibody is un-conjugated
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
71
42
34
19
16
13
9
8
2
1
1
1
Supplier
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Supplier Product No.
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very Cterminal residues of human OPRM1(Mu-type opioid receptor)
Alternative Name OPRM1 (OPRM1 Antibody Abstract)
Background OPRM1(Mu-type opioid receptor) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. OPRM1forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. OPRM1 interacts with RGSZ17 and RGSZ20. OPRM1 is a multi-pass membrane protein. The polymorphism Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. OPRM1(Mu-type opioid receptor) belongs to the G-protein coupled receptor 1 family.
Research Area Hormones, Receptors, Neurology
Pathways TCR Signaling
Restrictions For Research Use only
Product cited in: Xu, Xu, Hurd et al.: "Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." in: Journal of neurochemistry, Vol. 108, Issue 4, pp. 962-72, 2009 (PubMed).

Pan, Xu, Yu et al.: "Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." in: Neuroscience, Vol. 133, Issue 1, pp. 209-20, 2005 (PubMed).

Pan, Xu, Mahurter et al.: "Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." in: Biochemical and biophysical research communications, Vol. 301, Issue 4, pp. 1057-61, 2003 (PubMed).

Uhl, Sora, Wang: "The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 7752-5, 1999 (PubMed).

Bare, Mansson, Yang: "Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." in: FEBS letters, Vol. 354, Issue 2, pp. 213-6, 1994 (PubMed).

Wang, Johnson, Persico et al.: "Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." in: FEBS letters, Vol. 338, Issue 2, pp. 217-22, 1994 (PubMed).

Mestek, Hurley, Bye et al.: "The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 3 Pt 2, pp. 2396-406, 1995 (PubMed).