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CDKN1B antibody (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)) (pThr187)

Details for Product anti-CDKN1B Antibody No. ABIN966733, Supplier: Login to see
Antigen
  • CDKN1B
  • CIB
  • CIBP
  • KIP1
  • PRKDCIP
  • SIP2-28
  • p27Kip1
  • AA408329
  • AI843786
  • Kip1
  • p27
  • CDKN4
  • Cdki1b
  • P27KIP1
  • MEN1B
  • MEN4
  • cdkn1bl
  • cdkn1b
  • sb:cb611
  • wu:fb63g10
  • wu:fb64g10
  • wu:fe18e03
  • FAM14D
  • ISG12
  • ISG12A
  • P27
  • 1500011J20Rik
  • 2610202L11Rik
  • Bridge-1
Alternatives
anti-Human CDKN1B antibody for Immunohistochemistry (Frozen Sections)
Epitope
pThr187
111
59
44
36
28
23
21
20
20
20
20
16
15
15
14
14
13
13
9
8
8
8
6
6
6
6
5
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
590
202
144
21
21
16
10
7
6
5
3
2
2
2
2
1
1
Host
Rabbit
504
99
37
4
2
1
Conjugate
This CDKN1B antibody is un-conjugated
31
29
27
25
25
25
6
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
440
305
183
103
96
80
47
30
25
16
14
7
3
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p27Kip1 around the phosphorylation site of threonine 187 (E-Q-TP-P-K).
Specificity P27Kip1 (phospho-Thr187) antibody detects endogenous levels of p27Kip1 only when phosphorylated at threonine 187.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorrylation site.
Alternative Name p27Kip1 (CDKN1B Antibody Abstract)
Research Area Cancer, Cell Cycle
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Eguchi, Herschenhous, Kuzushita et al.: "Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells." in: Cancer research, Vol. 63, Issue 15, pp. 4739-46, 2003 (PubMed).

Le, Claret, Lammayot et al.: "The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23441-50, 2003 (PubMed).

Connor, Kotchetkov, Cariou et al.: "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 201-13, 2003 (PubMed).

Fujita, Sato, Katayama et al.: "Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization." in: The Journal of biological chemistry, Vol. 277, Issue 32, pp. 28706-13, 2002 (PubMed).

Background publications Ishida, Kitagawa, Hatakeyama et al.: "Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25146-54, 2000 (PubMed).