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CDKN1B antibody (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)) (pThr187)

Details for Product anti-CDKN1B Antibody No. ABIN966733, Supplier: Login to see New
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Antigen
Synonyms
CDKN1B, CIB, CIBP, KIP1, PRKDCIP, SIP2-28, p27Kip1, AA408329, AI843786, Kip1, p27, CDKN4, Cdki1b, P27KIP1, MEN1B, MEN4, cdkn1bl, cdkn1b, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18e03, FAM14D, ISG12, IS ... show more
CDKN1B, CIB, CIBP, KIP1, PRKDCIP, SIP2-28, p27Kip1, AA408329, AI843786, Kip1, p27, CDKN4, Cdki1b, P27KIP1, MEN1B, MEN4, cdkn1bl, cdkn1b, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18e03, FAM14D, ISG12, ISG12A, P27, 1500011J20Rik, 2610202L11Rik, Bridge-1 show less
Alternatives
Epitope
pThr187
(115), (60), (44), (37), (28), (23), (21), (20), (20), (20), (20), (16), (16), (15), (14), (14), (13), (13), (9), (8), (8), (8), (6), (6), (6), (6), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(599), (210), (147), (21), (21), (16), (10), (7), (6), (5), (3), (2), (2), (2), (2), (1), (1)
Host
Rabbit
(511), (105), (37), (4), (2), (1)
Conjugate
This CDKN1B antibody is un-conjugated
(31), (31), (27), (25), (25), (25), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC)
(449), (305), (183), (103), (102), (86), (51), (30), (29), (16), (14), (9), (3), (1), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p27Kip1 around the phosphorylation site of threonine 187 (E-Q-TP-P-K).
Specificity P27Kip1 (phospho-Thr187) antibody detects endogenous levels of p27Kip1 only when phosphorylated at threonine 187.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorrylation site.
Alternative Name p27Kip1 (CDKN1B Antibody Abstract)
Research Area Cancer, Cell Cycle
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Eguchi, Herschenhous, Kuzushita et al.: "Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells." in: Cancer research, Vol. 63, Issue 15, pp. 4739-46, 2003 (PubMed).

Le, Claret, Lammayot et al.: "The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23441-50, 2003 (PubMed).

Connor, Kotchetkov, Cariou et al.: "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 201-13, 2003 (PubMed).

Fujita, Sato, Katayama et al.: "Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization." in: The Journal of biological chemistry, Vol. 277, Issue 32, pp. 28706-13, 2002 (PubMed).

Background publications Ishida, Kitagawa, Hatakeyama et al.: "Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25146-54, 2000 (PubMed).

Catalog No. ABIN966733
$398.75
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