CDKN1B antibody (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)) (pThr187)

Details for Product anti-CDKN1B Antibody No. ABIN966733, Supplier: Log in to see
Antigen
  • CDKN1B
  • CIB
  • CIBP
  • KIP1
  • PRKDCIP
  • SIP2-28
  • p27Kip1
  • AA408329
  • AI843786
  • Kip1
  • p27
  • CDKN4
  • Cdki1b
  • P27KIP1
  • MEN1B
  • MEN4
  • cdkn1bl
  • cdkn1b
  • sb:cb611
  • wu:fb63g10
  • wu:fb64g10
  • wu:fe18e03
  • FAM14D
  • ISG12
  • ISG12A
  • P27
  • 1500011J20Rik
  • 2610202L11Rik
  • Bridge-1
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • calcium and integrin binding 1 (calmyrin)
  • cyclin kinase inhibitor p30 Kip1
  • cyclin-dependent kinase inhibitor 1B
  • cyclin-dependent kinase inhibitor 1Ba
  • cyclin-dependent kinase inhibitor 1Bb
  • interferon, alpha-inducible protein 27
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
  • CDKN1B
  • CIB1
  • LOC100689401
  • Cdkn1b
  • cdkn1ba
  • cdkn1bb
  • IFI27
  • Psmd9
Alternatives
anti-Human CDKN1B antibody for Immunofluorescence (fixed cells)
Epitope
pThr187
97
54
51
43
34
27
26
21
20
20
20
18
18
17
16
15
13
13
9
6
6
5
5
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
699
357
298
93
44
27
18
12
8
7
3
3
2
2
1
1
1
Host
Rabbit
475
220
36
3
2
1
Conjugate
This CDKN1B antibody is un-conjugated
37
34
32
31
25
25
9
9
7
7
5
5
5
5
5
5
5
5
5
4
4
3
3
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC)
531
325
200
167
159
102
101
99
53
37
28
14
10
3
3
1
1
1
Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p27Kip1 around the phosphorylation site of threonine 187 (E-Q-TP-P-K).
Specificity P27Kip1 (phospho-Thr187) antibody detects endogenous levels of p27Kip1 only when phosphorylated at threonine 187.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorrylation site.
Alternative Name p27Kip1 (CDKN1B Antibody Abstract)
Research Area Cancer, Cell Cycle
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Eguchi, Herschenhous, Kuzushita, Moss: "Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells." in: Cancer research, Vol. 63, Issue 15, pp. 4739-46, 2003 (PubMed).

Le, Claret, Lammayot, Tian, Deshpande, LaPushin, Tari, Bast: "The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23441-50, 2003 (PubMed).

Connor, Kotchetkov, Cariou, Resch, Lupetti, Beniston, Melchior, Hengst, Slingerland: "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 201-13, 2003 (PubMed).

Fujita, Sato, Katayama, Tsuruo: "Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization." in: The Journal of biological chemistry, Vol. 277, Issue 32, pp. 28706-13, 2002 (PubMed).

Background publications Ishida, Kitagawa, Hatakeyama, Nakayama: "Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25146-54, 2000 (PubMed).