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p53 antibody (Tumor Protein P53) (pSer15)

Details for Product anti-TP53 Antibody No. ABIN966755, Supplier: Login to see
Antigen
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
Alternatives
anti-Human p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
pSer15
86
65
65
53
51
51
51
50
50
48
41
40
38
33
26
24
22
20
20
19
17
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9
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3
3
2
2
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
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1
1
1
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1
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1
1
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Reactivity
Human
1739
312
256
71
30
11
11
10
10
10
9
7
5
4
4
4
4
3
3
2
2
2
1
Host
Rabbit
1223
605
8
4
3
1
1
Conjugate
This p53 antibody is un-conjugated
58
49
32
31
21
21
17
15
15
14
14
14
14
14
14
3
3
3
3
3
3
3
3
3
3
2
1
1
Application
Immunohistochemistry (IHC)
1357
565
511
333
330
302
225
160
106
94
54
35
33
18
16
13
11
11
11
9
4
3
3
3
2
2
2
1
1
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 15 (P-L-SP-Q-E).
Specificity P53 (phospho-Ser15) antibody detects endogenous levels of p53 only when phosphorylated at serine15.
Alternative Name p53 (TP53 Antibody Abstract)
Research Area Cancer, Cell Cycle, Transcription Factors, DNA/RNA, Apoptosis/Necrosis
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Shieh, Taya, Prives: "DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization." in: The EMBO journal, Vol. 18, Issue 7, pp. 1815-23, 1999 (PubMed).

Background publications Hirao, Kong, Matsuoka et al.: "DNA damage-induced activation of p53 by the checkpoint kinase Chk2." in: Science (New York, N.Y.), Vol. 287, Issue 5459, pp. 1824-7, 2000 (PubMed).

Honda, Tanaka, Yasuda: "Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53." in: FEBS letters, Vol. 420, Issue 1, pp. 25-7, 1998 (PubMed).