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p53 antibody (Tumor Protein P53) (pSer315)

Details for Product anti-TP53 Antibody No. ABIN966756, Supplier: Log in to see
Antigen
  • bbl
  • BCC7
  • bfy
  • bhy
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • LFS1
  • p44
  • P53
  • p53
  • tp53
  • TP53
  • Tp53
  • TpMs
  • Trp53
  • TRP53
  • wu:fb40d06
  • Xp53
  • zgc:111919
Alternatives
anti-Human p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
pSer315
156
103
87
67
66
64
56
52
52
52
47
46
42
40
31
30
28
25
25
22
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2
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1
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Reactivity
Human
2086
394
328
120
101
89
56
54
29
23
19
15
14
10
10
5
5
4
4
3
3
3
3
2
2
Host
Rabbit
1253
931
7
4
3
1
1
Conjugate
This p53 antibody is un-conjugated
68
61
49
45
31
31
30
23
23
17
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6
4
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1
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Application
Immunohistochemistry (IHC)
1659
732
563
492
442
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397
230
194
170
53
38
35
17
16
12
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9
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4
3
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2
2
2
1
1
1
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1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q).
Specificity P53 (phospho-Ser315) antibody detects endogenous levels of p53 only when phosphorylated at serine 315.
Alternative Name p53 (TP53 Antibody Abstract)
Research Area Cancer, Cell Cycle, Transcription Factors, DNA/RNA, Apoptosis/Necrosis
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Pospísilová, Brázda, Kucharíková, Luciani, Hupp, Skládal, Palecek, Vojtesek: "Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 939-47, 2004 (PubMed).

Lu, Fisher, Bailey, Levine: "The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5923-34, 1997 (PubMed).

Lohrum, Scheidtmann: "Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes." in: Oncogene, Vol. 13, Issue 12, pp. 2527-39, 1997 (PubMed).

Ullrich, Sakaguchi, Lees-Miller, Fiscella, Mercer, Anderson, Appella: "Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 13, pp. 5954-8, 1993 (PubMed).

Product cited in: Merrick, Zhou, Martin, Jeyarajah, Parker, Selkirk, Tomer, Borchers: "Site-specific phosphorylation of human p53 protein determined by mass spectrometry." in: Biochemistry, Vol. 40, Issue 13, pp. 4053-66, 2001 (PubMed).