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p53 antibody (Tumor Protein P53) (pSer315)

Details for Product anti-TP53 Antibody No. ABIN966756, Supplier: Login to see New
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Antigen
Synonyms tp53, p53, TP53, Tp53, bbl, bfy, bhy, p44, TpMs, BCC7, LFS1, P53, TRP53, Trp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919
Alternatives
Epitope
pSer315
(87), (69), (64), (53), (53), (51), (51), (50), (50), (48), (40), (40), (38), (33), (26), (25), (22), (21), (20), (19), (17), (13), (13), (13), (13), (13), (13), (12), (11), (10), (10), (9), (9), (9), (9), (9), (8), (8), (8), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(1804), (322), (258), (71), (30), (11), (11), (10), (10), (10), (9), (7), (5), (4), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1)
Host
Rabbit
(1264), (638), (8), (4), (3), (1), (1)
Conjugate
This p53 antibody is un-conjugated
(59), (50), (32), (31), (21), (21), (17), (15), (15), (14), (14), (14), (14), (14), (14), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(1404), (570), (517), (368), (351), (315), (236), (160), (114), (100), (54), (35), (33), (19), (18), (18), (16), (13), (11), (9), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q).
Specificity P53 (phospho-Ser315) antibody detects endogenous levels of p53 only when phosphorylated at serine 315.
Alternative Name p53 (TP53 Antibody Abstract)
Research Area Cancer, Cell Cycle, Transcription Factors, DNA/RNA, Apoptosis/Necrosis
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Merrick, Zhou, Martin et al.: "Site-specific phosphorylation of human p53 protein determined by mass spectrometry." in: Biochemistry, Vol. 40, Issue 13, pp. 4053-66, 2001 (PubMed).

Background publications Pospísilová, Brázda, Kucharíková et al.: "Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 939-47, 2004 (PubMed).

Lu, Fisher, Bailey et al.: "The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5923-34, 1997 (PubMed).

Lohrum, Scheidtmann: "Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes." in: Oncogene, Vol. 13, Issue 12, pp. 2527-39, 1997 (PubMed).

Ullrich, Sakaguchi, Lees-Miller et al.: "Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 13, pp. 5954-8, 1993 (PubMed).

Catalog No. ABIN966756
$398.75
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