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p53 antibody (Tumor Protein P53) (pSer46)

Details for Product anti-TP53 Antibody No. ABIN966757, Supplier: Log in to see
Antigen
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
Alternatives
anti-Human p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
pSer46
121
86
62
54
51
50
49
48
46
46
43
40
39
31
27
25
22
19
19
17
17
13
13
13
13
13
12
12
9
9
9
8
8
8
8
8
8
8
7
7
7
6
6
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6
6
6
6
5
5
5
5
5
4
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4
4
4
4
4
4
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4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
1
1
1
1
1
1
1
1
1
1
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1
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1
1
1
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1
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1
1
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1
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1
Reactivity
Human
1756
319
270
97
34
18
14
11
11
10
10
9
5
4
4
4
3
3
3
2
2
2
1
Host
Rabbit
1237
605
7
4
3
1
1
Conjugate
This p53 antibody is un-conjugated
48
44
31
27
20
20
17
15
15
14
14
14
14
14
14
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC)
1370
575
525
316
313
300
234
160
98
79
53
39
35
17
16
11
11
11
11
9
4
3
3
3
2
2
2
1
1
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D).
Specificity P53 (phospho-Ser46) antibody detects endogenous levels of p53 only when phosphorylated at serine 46.
Alternative Name p53 (TP53 Antibody Abstract)
Research Area Cancer, Cell Cycle, Transcription Factors, DNA/RNA, Apoptosis/Necrosis
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Mayo, Seo, Jackson et al.: "Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified." in: The Journal of biological chemistry, Vol. 280, Issue 28, pp. 25953-9, 2005 (PubMed).

Background publications Di Stefano, Soddu, Sacchi et al.: "HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage." in: Oncogene, Vol. 24, Issue 35, pp. 5431-42, 2005 (PubMed).

Dhavan, Tsai: "A decade of CDK5." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 10, pp. 749-59, 2001 (PubMed).

Patrick, Zhou, Kwon et al.: "p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24057-64, 1998 (PubMed).