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p53 antibody (Tumor Protein P53) (pSer46)

Details for Product anti-TP53 Antibody No. ABIN966757, Supplier: Log in to see
Antigen
  • bbl
  • BCC7
  • bfy
  • bhy
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • LFS1
  • p44
  • P53
  • p53
  • tp53
  • TP53
  • Tp53
  • TpMs
  • Trp53
  • TRP53
  • wu:fb40d06
  • Xp53
  • zgc:111919
Alternatives
anti-Human p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
pSer46
156
103
87
67
66
65
56
52
52
51
47
46
42
40
31
30
28
25
25
22
22
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20
17
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4
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4
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3
3
3
3
3
3
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3
3
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2
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
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1
1
1
1
1
1
1
1
1
1
1
1
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1
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1
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Reactivity
Human
2086
394
328
120
101
89
56
54
29
23
19
15
14
10
10
5
5
4
4
3
3
3
3
2
2
Host
Rabbit
1253
931
7
4
3
1
1
Conjugate
This p53 antibody is un-conjugated
68
61
49
45
31
31
30
23
23
17
17
16
16
14
14
14
14
14
14
13
13
13
13
13
12
12
6
4
4
4
4
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4
4
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3
3
1
1
Application
Immunohistochemistry (IHC)
1659
732
563
492
442
421
397
230
194
170
53
38
35
17
16
12
12
11
11
9
9
4
3
3
3
2
2
2
1
1
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D).
Specificity P53 (phospho-Ser46) antibody detects endogenous levels of p53 only when phosphorylated at serine 46.
Alternative Name p53 (TP53 Antibody Abstract)
Research Area Cancer, Cell Cycle, Transcription Factors, DNA/RNA, Apoptosis/Necrosis
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Di Stefano, Soddu, Sacchi, DOrazi: "HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage." in: Oncogene, Vol. 24, Issue 35, pp. 5431-42, 2005 (PubMed).

Dhavan, Tsai: "A decade of CDK5." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 10, pp. 749-59, 2001 (PubMed).

Patrick, Zhou, Kwon, Howley, Tsai: "p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24057-64, 1998 (PubMed).

Product cited in: Mayo, Seo, Jackson, Smith, Rivera Guzman, Korgaonkar, Donner: "Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified." in: The Journal of biological chemistry, Vol. 280, Issue 28, pp. 25953-9, 2005 (PubMed).