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p53 antibody (Tumor Protein P53) (pSer46)

Details for Product anti-TP53 Antibody No. ABIN966757, Supplier: Login to see New
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Antigen
Synonyms tp53, p53, TP53, Tp53, bbl, bfy, bhy, p44, TpMs, BCC7, LFS1, P53, TRP53, Trp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919
Alternatives
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Epitope
pSer46
(86), (65), (65), (53), (52), (51), (51), (50), (49), (48), (41), (40), (38), (33), (26), (24), (22), (20), (19), (19), (17), (13), (13), (13), (13), (13), (13), (12), (10), (10), (9), (9), (9), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(1738), (310), (256), (71), (30), (11), (11), (10), (10), (10), (9), (7), (5), (4), (4), (4), (4), (3), (3), (2), (2), (2), (1)
Host
Rabbit
(1223), (604), (8), (4), (3), (1), (1)
Conjugate
This p53 antibody is un-conjugated
(58), (49), (32), (31), (21), (21), (17), (15), (15), (14), (14), (14), (14), (14), (14), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1)
Application
Immunohistochemistry (IHC)
(1357), (565), (511), (333), (330), (303), (225), (160), (106), (92), (54), (35), (33), (18), (16), (13), (11), (11), (11), (9), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D).
Specificity P53 (phospho-Ser46) antibody detects endogenous levels of p53 only when phosphorylated at serine 46.
Alternative Name p53 (TP53 Antibody Abstract)
Research Area Cancer, Cell Cycle, Transcription Factors, DNA/RNA, Apoptosis/Necrosis
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Mayo, Seo, Jackson et al.: "Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified." in: The Journal of biological chemistry, Vol. 280, Issue 28, pp. 25953-9, 2005 (PubMed).

Background publications Di Stefano, Soddu, Sacchi et al.: "HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage." in: Oncogene, Vol. 24, Issue 35, pp. 5431-42, 2005 (PubMed).

Dhavan, Tsai: "A decade of CDK5." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 10, pp. 749-59, 2001 (PubMed).

Patrick, Zhou, Kwon et al.: "p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24057-64, 1998 (PubMed).

Catalog No. ABIN966757
$398.75
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