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Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) (pTyr398) antibody

Details for Product No. ABIN966765, Supplier: Log in to see
Antigen
  • 4432404K01Rik
  • ARTC4
  • DO
  • DOK1
  • AW557123
  • p62DOK
  • Dok-1
  • P62DOK
Epitope
pTyr398
41
39
22
13
11
7
7
5
4
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
210
117
112
2
Host
Rabbit
205
5
Conjugate
Un-conjugated
8
8
8
3
3
3
3
3
3
3
3
3
2
2
2
Application
Immunohistochemistry (IHC)
161
85
52
33
28
13
7
4
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p62Dok around the phosphorylation site of tyrosine 398 (E-G-YP-E-L).
Specificity P62Dok (phospho-Tyr398) antibody detects endogenous levels of p62Dok only when phosphorylated at tyrosine 398.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name p62Dok (DOK1 Antibody Abstract)
Pathways
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Simoncic, Bourdeau, Lee-Loy et al.: "T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4149-60, 2006 (PubMed).

Yopp, Ochando, Mao et al.: "Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2913-24, 2005 (PubMed).

Wick, Dong, Hu et al.: "Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt." in: The Journal of biological chemistry, Vol. 276, Issue 46, pp. 42843-50, 2001 (PubMed).