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Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) (pTyr398) antibody

Antigen

Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1)
Synonyms P62DOK, MGC117395, MGC138860
Binding Site
Alternatives

pTyr398
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
3 references available
Catalog no. ABIN966765
Quantity 100ug  (100ug/100ul.)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name p62Dok
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p62Dok around the phosphorylation site of tyrosine 398 (E-G-YP-E-L).
Specificity P62Dok (phospho-Tyr398) antibody detects endogenous levels of p62Dok only when phosphorylated at tyrosine 398.

Application Details
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Application Notes WB: 1:500~1:1000.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Wick, Dong, Hu et al.: "Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt." in: The Journal of biological chemistry, Vol. 276, Issue 46, pp. 42843-50, 2001 (PubMed).

Yopp, Ochando, Mao et al.: "Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2913-24, 2005 (PubMed).

Simoncic, Bourdeau, Lee-Loy et al.: "T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4149-60, 2006 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1)", type "Antibodies"
Hosts Rabbit (100)
Reactivities Human (100), Mouse (Murine) (55), Rat (Rattus) (54), Cow (Bovine) (29), Dog (Canine) (29), Pig (Porcine) (28), Horse (Equine) (5), Cat (Feline) (1), Chicken (1)
Applications Western Blotting (WB) (66), Immunofluorescence (IF) (34), Immunohistochemistry (IHC) (32), ELISA (21), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Flow Cytometry (FACS) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr362 (15), pTyr398 (13), C-Term (7), N-Term (4), Tyr362 (4), Tyr398 (4), AA 24-39 (2), Internal Region (2), AA 425-439 (1), pSer213 (1)