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PKC theta antibody (Protein Kinase C, theta) (pSer695)

Details for Product anti-PRKCQ Antibody No. ABIN966840, Supplier: Log in to see
Antigen
  • PRKCT
  • nPKC-theta
  • A130035A12Rik
  • AW494342
  • PKC-0
  • PKC-theta
  • PKCtheta
  • Pkcq
  • protein kinase C, theta
  • protein kinase C theta
  • PRKCQ
  • PKC
  • Prkcq
Alternatives
anti-Human PKC theta antibody for Western Blotting
Epitope
pSer695
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42
38
10
10
9
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
214
140
131
11
10
9
7
3
2
1
1
Host
Rabbit
215
15
3
1
Conjugate
This PKC theta antibody is un-conjugated
5
5
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4
4
3
3
3
3
3
3
3
2
2
1
1
Application
Immunohistochemistry (IHC)
164
113
75
40
40
35
8
6
6
3
3
2
1
1
1
1
Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PKC around the phosphorylation site of serine 695 (N-F-SP-F-M).
Specificity PKC (phospho-Ser695) antibody detects endogenous levels of PKC only when phosphorylated at serine 695.
Alternative Name PKCtheta (PRKCQ Antibody Abstract)
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Myometrial Relaxation and Contraction
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Kim, Sekiya, Poulin, Bae, Rhee: "Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 9986-99, 2004 (PubMed).

Humphries, Dangelmaier, Sommer, Kipp, Kato, Griffith, Bakman, Turk, Daniel, Rawlings: "Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37651-61, 2004 (PubMed).

Suzuki-Inoue, Wilde, Andrews, Auger, Siraganian, Sekiya, Rhee, Watson: "Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 1023-9, 2004 (PubMed).

Rodriguez, Matsuda, Storey, Katan: "Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling." in: The Biochemical journal, Vol. 374, Issue Pt 1, pp. 269-80, 2003 (PubMed).