Phospholipase C gamma 2 antibody (PLCG2) (pTyr753)

Details for Product anti-PLCG2 Antibody No. ABIN966862, Supplier: Log in to see
Antigen
  • PLCgamma2
  • Plcg-2
  • APLAID
  • FCAS3
  • phospholipase C, gamma 2
  • phospholipase C, gamma 2 (phosphatidylinositol-specific)
  • Plcg2
  • PLCG2
Alternatives
anti-Human Phospholipase C gamma 2 antibody for Immunofluorescence (fixed cells)
Epitope
pTyr753
44
29
23
21
15
5
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
270
156
147
12
4
4
4
4
3
1
Host
Rabbit
200
70
Conjugate
This Phospholipase C gamma 2 antibody is un-conjugated
7
7
6
6
6
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Application
Immunohistochemistry (IHC)
185
104
81
55
43
40
39
16
13
4
3
3
2
1
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PLC2 around the phosphorylation site of tyrosine 753 (S-L-YP-D-V).
Specificity PLC2 (phospho-Tyr753) antibody detects endogenous levels of PLC2 only when phosphorylated at tyrosine 753.
Alternative Name PLCgamma2 (PLCG2 Antibody Abstract)
Pathways RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Kim, Sekiya, Poulin, Bae, Rhee: "Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 9986-99, 2004 (PubMed).

Humphries, Dangelmaier, Sommer, Kipp, Kato, Griffith, Bakman, Turk, Daniel, Rawlings: "Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37651-61, 2004 (PubMed).

Suzuki-Inoue, Wilde, Andrews, Auger, Siraganian, Sekiya, Rhee, Watson: "Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 1023-9, 2004 (PubMed).

Rodriguez, Matsuda, Storey, Katan: "Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling." in: The Biochemical journal, Vol. 374, Issue Pt 1, pp. 269-80, 2003 (PubMed).