Phospholipase C gamma 2 (PLCG2) (pTyr753) antibody

Details for Product No. ABIN966862
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Antigen
Synonyms PLCgamma2, Plcg-2, APLAID, FCAS3
Epitope
pTyr753
(42), (40), (17), (17), (12), (5), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(210), (126), (125), (1)
Host
Rabbit
(204), (6)
Conjugate
Un-conjugated
(5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1)
Application
Immunohistochemistry (IHC)
(121), (76), (41), (40), (39), (35), (13), (7), (3), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human PLC2 around the phosphorylation site of tyrosine 753 (S-L-YP-D-V).
Specificity PLC2 (phospho-Tyr753) antibody detects endogenous levels of PLC2 only when phosphorylated at tyrosine 753.
Alternative Name PLCgamma2 (PLCG2 Antibody Abstract)
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Kim, Sekiya, Poulin et al.: "Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 9986-99, 2004 (PubMed).

Humphries, Dangelmaier, Sommer et al.: "Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37651-61, 2004 (PubMed).

Suzuki-Inoue, Wilde, Andrews et al.: "Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 1023-9, 2004 (PubMed).

Rodriguez, Matsuda, Storey et al.: "Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling." in: The Biochemical journal, Vol. 374, Issue Pt 1, pp. 269-80, 2003 (PubMed).

Validation Images
Catalog No. ABIN966862
398.75 $
Plus shipping costs $45.00
Quantity
Price
100 μg
398.75 $

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