Polo-Like Kinase 1 (PLK1) (pThr210) antibody

Details for Product No. ABIN966867
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Antigen
Synonyms PLK, STPK13, plk, Plk, cb525, cb636, ik:tdsubc_2d1, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1, PLK-1, Plx1, stpk13
Epitope
pThr210
(34), (19), (9), (6), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(155), (77), (71), (46), (38), (30), (14), (6), (5), (4), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(112), (49), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunohistochemistry (IHC)
(125), (65), (38), (31), (30), (25), (23), (7), (4), (3), (2), (2), (1)
Pubmed 7 references available
Catalog no. ABIN966867
Quantity 0.1 mg
Price
452.38 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to Nresidues of human PLK1(Serine/threonine-protein kinase PLK1) (Polo-like kinase 1)
Alternative Name PLK1
Background PLK1(Serine/threonine-protein kinase) that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. PLK1 is activated by serine and threonine phosphorylation. PLK1 interacts with CEP170 and EVI5. PLK1 interacts and phosphorylates ERCC6L. PLK1 accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase. Autophosphorylation and phosphorylation of Ser-137 are not significant events during activation of PLK1 in M phase.
Synonyms: PLK
Research Area Cancer, Cell Cycle, Kinases/Phosphatases
Restrictions For Research Use only
Product cited in: Bräuninger, Strebhardt, Rübsamen-Waigmann: "Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter." in: Oncogene, Vol. 11, Issue 9, pp. 1793-800, 1995 (PubMed).

Lake, Jelinek: "Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase." in: Molecular and cellular biology, Vol. 13, Issue 12, pp. 7793-801, 1994 (PubMed).

Golsteyn, Schultz, Bartek et al.: "Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5." in: Journal of cell science, Vol. 107 ( Pt 6), pp. 1509-17, 1994 (PubMed).

Uchiumi, Longo, Ferris: "Cell cycle regulation of the human polo-like kinase (PLK) promoter." in: The Journal of biological chemistry, Vol. 272, Issue 14, pp. 9166-74, 1997 (PubMed).

Lee, Erikson: "Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures." in: Molecular and cellular biology, Vol. 17, Issue 6, pp. 3408-17, 1997 (PubMed).

Jang, Ma, Terada et al.: "Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44115-20, 2002 (PubMed).

Wind, Kelm, Nigg et al.: "Identification of phosphorylation sites in the polo-like kinases Plx1 and Plk1 by a novel strategy based on element and electrospray high resolution mass spectrometry." in: Proteomics, Vol. 2, Issue 11, pp. 1516-23, 2002 (PubMed).

Hosts (112), (49), (2)
Reactivities (155), (77), (71), (46), (38), (30), (14), (6), (5), (4), (2), (1), (1), (1), (1), (1)
Applications (125), (65), (38), (31), (30), (25), (23), (7), (4), (3), (2), (2), (1)
Conjugates (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (34), (19), (9), (6), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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