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Polymerase (DNA Directed), beta (POLB) (2meArg83), (N-Term) antibody

Details for Product No. ABIN966879, Supplier: Log in to see
Antigen
  • wu:fa97a05
  • zgc:109924
  • POLB
  • DDBDRAFT_0186152
  • DDBDRAFT_0215784
  • DDBDRAFT_0232376
  • DDB_0186152
  • DDB_0215784
  • DDB_0232376
  • A430088C08Rik
Alternatives
anti-Human Polymerase (DNA Directed), beta antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
N-Term, 2meArg83
13
12
5
4
3
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
83
48
39
4
2
2
2
Host
Rabbit
62
30
Clonality
Polyclonal
Conjugate
Un-conjugated
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
71
34
24
15
11
11
8
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human POLB (DNA polymerase beta)
Alternative Name POLB (POLB Antibody Abstract)
Background POLB (DNA polymerase beta) is a repair polymerase. POLB conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. POLB has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. POLB binds 2 magnesium ions per subunit (By similarity).POLB belongs to the DNA polymerase type-X family.
Pathways DNA Damage Repair
Restrictions For Research Use only
Product cited in: El-Andaloussi, Valovka, Toueille et al.: "Arginine methylation regulates DNA polymerase beta." in: Molecular cell, Vol. 22, Issue 1, pp. 51-62, 2006 (PubMed).

DeMott, Beyret, Wong et al.: "Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone." in: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 7637-40, 2002 (PubMed).

Patterson, Little, Cheng et al.: "Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes." in: Protein expression and purification, Vol. 18, Issue 1, pp. 100-10, 2000 (PubMed).

Matsumoto, Kim, Katz et al.: "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups." in: Biochemistry, Vol. 37, Issue 18, pp. 6456-64, 1998 (PubMed).

Chyan, Ackerman, Shepherd et al.: "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression." in: Nucleic acids research, Vol. 22, Issue 14, pp. 2719-25, 1994 (PubMed).

Dobashi, Kubota, Shuin et al.: "Polymorphisms in the human DNA polymerase beta gene." in: Human genetics, Vol. 95, Issue 4, pp. 389-90, 1995 (PubMed).

Abbotts, SenGupta, Zmudzka et al.: "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme." in: Biochemistry, Vol. 27, Issue 3, pp. 901-9, 1988 (PubMed).

Widen, Kedar, Wilson: "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter." in: The Journal of biological chemistry, Vol. 263, Issue 32, pp. 16992-8, 1988 (PubMed).

SenGupta, Zmudzka, Kumar et al.: "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning." in: Biochemical and biophysical research communications, Vol. 136, Issue 1, pp. 341-7, 1986 (PubMed).