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Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) (C-Term) antibody

Details for Product No. ABIN966880, Supplier: Log in to see
Antigen
  • polrmt-a
  • mtRPO
  • wu:fb73g10
  • si:dkeyp-74c5.5
  • POLRMT
  • APOLMT
  • MTRNAP
  • MTRPOL
  • h-mtRPOL
  • 1110018N15Rik
  • 4932416K13
Epitope
C-Term
5
3
2
1
1
1
1
1
1
Reactivity
Human
15
1
1
1
Host
Rabbit
7
5
3
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
11
9
2
1
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human POLRMT(DNA-directed RNA polymerase, mitochondrial)
Alternative Name POLRMT (POLRMT Antibody Abstract)
Background POLRMT(DNA-directed RNA polymerase, mitochondrial) is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNAdirected RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. POLRMT(DNA-directed RNA polymerase, mitochondrial) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLRMT interacts with TFB1M and TFB2M, leading to the stimulation of family.
Restrictions For Research Use only
Product cited in: Bogenhagen, Rousseau, Burke: "The layered structure of human mitochondrial DNA nucleoids." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3665-75, 2008 (PubMed).

Kravchenko, Rogozin, Koonin et al.: "Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin." in: Nature, Vol. 436, Issue 7051, pp. 735-9, 2005 (PubMed).

Gaspari, Falkenberg, Larsson et al.: "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells." in: The EMBO journal, Vol. 23, Issue 23, pp. 4606-14, 2004 (PubMed).

Tiranti, Savoia, Forti et al.: "Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database." in: Human molecular genetics, Vol. 6, Issue 4, pp. 615-25, 1997 (PubMed).

Background publications Wang, Cotney, Shadel: "Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression." in: The Journal of biological chemistry, Vol. 282, Issue 17, pp. 12610-8, 2007 (PubMed).