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Presenilin 2 antibody (Presenilin 2 (Alzheimer Disease 4)) (N-Term)

Details for Product anti-PSEN2 Antibody No. ABIN966891, Supplier: Log in to see
Antigen
  • PSEN2
  • ad4
  • ps2
  • ad3l
  • stm2
  • ALG-3
  • Ad4h
  • Alg3
  • PS-2
  • PS2
  • Psnl2
  • STM2
  • pre2
  • zf-PS2
  • AD3L
  • AD4
  • CMD1V
  • PSNL2
  • presenilin 2 (Alzheimer disease 4)
  • presenilin 2
  • presenilin-2-like
  • PSEN2
  • psen2
  • Psen2
  • LOC100717114
Alternatives
anti-Human Presenilin 2 antibody for Immunohistochemistry (Frozen Sections)
Epitope
N-Term
17
7
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
137
81
74
32
7
5
5
4
3
3
3
2
2
2
2
1
1
1
1
Host
Rabbit
72
43
18
3
2
Clonality
Polyclonal
Conjugate
This Presenilin 2 antibody is un-conjugated
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
101
70
60
54
37
33
19
13
11
8
2
2
1
1
1
Options
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human Presenilin-2, different from the related mouse and rat sequences by two amino acids.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Presenilin-2 ( PSEN2) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.
Alternative Name Presenilin-2(PS-2) (PSEN2 Antibody Abstract)
Background Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. [1]Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes. In melanocytic cells PSEN2 gene expression may be regulated by MITF. [2]
Pathways Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Hoek, Schlegel, Eichhoff, Widmer, Praetorius, Einarsson, Valgeirsdottir, Bergsteinsdottir, Schepsky, Dummer, Steingrimsson: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, 2008 (PubMed).

Kaplan, Renbaum, Vreman, Wong, Levy-Lahad, Hammerman, Stevenson: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, 2007 (PubMed).

Levy-Lahad, Wijsman, Nemens, Anderson, Goddard, Weber, Bird, Schellenberg: "A familial Alzheimer's disease locus on chromosome 1." in: Science (New York, N.Y.), Vol. 269, Issue 5226, pp. 970-3, 1995 (PubMed).