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PTK2B antibody (PTK2B Protein tyrosine Kinase 2 beta) (pTyr402)

Details for Product anti-PTK2B Antibody No. ABIN966926, Supplier: Login to see New
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Antigen
Synonyms Akt, PKB, Rac, PKB/Akt, PKBalpha, CADTK, CAKB, FADK2, FAK2, PTK, PYK2, RAFTK, CAKbeta, Pyk2, E430023O05Rik, Raftk
Alternatives
Epitope
pTyr402
(48), (19), (18), (15), (13), (13), (11), (11), (9), (9), (7), (6), (6), (6), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(236), (133), (118), (6), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(206), (35), (2)
Conjugate
This PTK2B antibody is un-conjugated
(6), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2)
Application
Immunohistochemistry (IHC)
(188), (107), (93), (40), (33), (28), (20), (6), (3), (2), (1), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Pyk2 around the phosphorylation site of tyrosine 402 (D-I-YP-A-E).
Specificity Pyk2 (phospho-Tyr402) antibody detects endogenous levels of Pyk2 only when phosphorylated at tyrosine 402.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name Pyk2 (PTK2B Antibody Abstract)
Pathways TCR Signaling, EGFR Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Krishnan, Sharma-Walia, Streblow et al.: "Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells." in: Journal of virology, Vol. 80, Issue 3, pp. 1167-80, 2006 (PubMed).

Gluck: "Acid sensing in renal epithelial cells." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1696-9, 2004 (PubMed).

Benzing, Gerke, Höpker et al.: "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 17, pp. 9784-9, 2001 (PubMed).

Background publications Tian, Litvak, Toledo-Rodriguez et al.: "Nir2, a novel regulator of cell morphogenesis." in: Molecular and cellular biology, Vol. 22, Issue 8, pp. 2650-62, 2002 (PubMed).

Lu, Jiang, Blume-Jensen et al.: "Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase." in: Molecular and cellular biology, Vol. 21, Issue 12, pp. 4016-31, 2001 (PubMed).

Catalog No. ABIN966926
$398.75
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