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Details for Product No. ABIN966949

Retinoblastoma 1 (RB1) antibody

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Antigen
Synonyms RB, pRb, OSRC, pp110, p105-Rb, Rb, Rb-1, P105-RB, PP110, RB11, zgc:154147, RB1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), ELISA
Pubmed 2 references available
Catalog no. ABIN966949
Quantity 0.1 mL
Price
261.25 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human RB expressed in E. Coli.
Clone 7E4B8
Isotype IgG1
Purification Ascitic fluid
Alternative Name RB
Background The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
Synonyms: RB, pRb, OSRC, pp110, p105-Rb, RB1
Gene ID 5925
Application Notes Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Preservative Sodium azide
Storage 4 °C
Product cited in: Weinberg: "The retinoblastoma protein and cell cycle control." in: Cell, Vol. 81, Issue 3, pp. 323-30, 1995 (PubMed).

Barrientes, Cooke, Goodrich: "Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function." in: Oncogene, Vol. 19, Issue 4, pp. 562-70, 2000 (PubMed).

Alternatives for antigen "Retinoblastoma 1 (RB1)", type "Antibodies"
Hosts (357), (105), (2)
Reactivities (446), (239), (223), (109), (87), (76), (48), (3), (2), (1), (1), (1), (1)
Applications (302), (134), (131), (100), (100), (74), (45), (20), (19), (16), (13), (2), (1)
Conjugates (13), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Epitopes (41), (36), (33), (24), (23), (21), (20), (20), (18), (18), (17), (7), (7), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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