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Retinoblastoma 1 (RB1) antibody

Details for Product No. ABIN966949
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Antigen
Synonyms RB, pRb, OSRC, pp110, p105-Rb, Rb, Rb-1, P105-RB, PP110, RB11, zgc:154147, RB1
Reactivity
Human
(331), (217), (204), (109), (85), (70), (48), (1), (1), (1)
Host
Mouse
(287), (55), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Application
Immunohistochemistry (IHC), ELISA
(209), (100), (94), (90), (82), (33), (25), (13), (10), (7), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
Options
Shipping to United States (Change)
Availability Will be delivered in 5 to 7 Business Days
Catalog No. ABIN966949
261.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of human RB expressed in E. Coli.
Clone 7E4B8
Isotype IgG1
Purification Ascitic fluid
Alternative Name RB
Background The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
Synonyms: RB, pRb, OSRC, pp110, p105-Rb, RB1
Gene ID 5925
Application Notes Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Weinberg: "The retinoblastoma protein and cell cycle control." in: Cell, Vol. 81, Issue 3, pp. 323-30, 1995 (PubMed).

Barrientes, Cooke, Goodrich: "Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function." in: Oncogene, Vol. 19, Issue 4, pp. 562-70, 2000 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN966949
261.25 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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