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Retinoblastoma 1 antibody (RB1)

Details for Product anti-RB1 Antibody No. ABIN966949, Supplier: Login to see New
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Antigen
Synonyms RB1, OSRC, RB, p105-Rb, pRb, pp110, Rb, Rb-1, zgc:154147, P105-RB, PP110, RB11
Alternatives
Reactivity
Human
(534), (261), (237), (11), (8), (7), (5), (5), (4), (4), (3), (3), (2), (2)
Host
Mouse
(475), (68), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
This Retinoblastoma 1 antibody is un-conjugated
(22), (20), (20), (15), (13), (13), (10), (9), (9), (7), (7), (7), (7), (7), (7)
Application
Immunohistochemistry (IHC), ELISA
(331), (214), (182), (83), (82), (74), (44), (35), (16), (13), (10), (8), (6), (5), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mL
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Immunogen Purified recombinant fragment of human RB expressed in E. Coli.
Clone 7E4B8
Isotype IgG1
Purification Ascitic fluid
Alternative Name RB (RB1 Antibody Abstract)
Background The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
Synonyms: RB, pRb, OSRC, pp110, p105-Rb, RB1
Gene ID 5925
Pathways Cell Division Cycle
Application Notes Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Barrientes, Cooke, Goodrich: "Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function." in: Oncogene, Vol. 19, Issue 4, pp. 562-70, 2000 (PubMed).

Weinberg: "The retinoblastoma protein and cell cycle control." in: Cell, Vol. 81, Issue 3, pp. 323-30, 1995 (PubMed).

Catalog No. ABIN966949
$275.00
Plus shipping costs $45.00

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