Retinoblastoma 1 (RB1) (pSer795) antibody

Details for Product No. ABIN966951
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Antigen
Synonyms RB1, OSRC, RB, p105-Rb, pRb, pp110, Rb, Rb-1, zgc:154147, P105-RB, PP110, RB11
Epitope
pSer795
(31), (31), (28), (21), (19), (19), (17), (17), (17), (14), (12), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(339), (226), (214), (109), (85), (65), (48), (7), (1), (1), (1)
Host
Rabbit
(298), (54), (2)
Conjugate
Un-conjugated
(10), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Application
Immunohistochemistry (IHC)
(213), (100), (93), (88), (80), (34), (31), (18), (11), (7), (2), (1)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN966951
385.00 $
Plus shipping costs $45.00

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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Rb around the phosphorylation site of serine 795 (P-S-SP-P-L).
Specificity Rb (phospho-Ser795) antibody detects endogenous levels of Rb only when phosphorylated at serine 795 Tested
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Rb
Research Area Cancer, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Roesch, Becker, Meyer et al.: "Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 4, pp. 565-72, 2005 (PubMed).

Leibundgut, Schmitz, Hirt: "Catalytic activities of G1 cyclin-dependent kinases and phosphorylation of retinoblastoma protein in mobilized peripheral blood CD34+ hematopoietic progenitor cells." in: Stem cells (Dayton, Ohio), Vol. 23, Issue 7, pp. 1002-11, 2005 (PubMed).

Wallick, Gamper, Thorne et al.: "Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells." in: Oncogene, Vol. 24, Issue 36, pp. 5606-18, 2005 (PubMed).

Rubin, Gall, Zheng et al.: "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release." in: Cell, Vol. 123, Issue 6, pp. 1093-106, 2005 (PubMed).

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