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Retinoblastoma 1 antibody (RB1) (pSer807)

Details for Product anti-RB1 Antibody No. ABIN966952, Supplier: Log in to see
Antigen
  • OSRC
  • P105-RB
  • p105-Rb
  • PP110
  • pp110
  • pRb
  • RB
  • Rb
  • Rb-1
  • RB1
  • RB11
  • zgc:154147
Alternatives
anti-Human Retinoblastoma 1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
pSer807
51
50
47
39
35
28
25
18
16
16
15
13
9
8
8
7
7
7
6
6
5
5
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
485
247
223
11
8
5
5
4
4
3
3
2
2
Host
Rabbit
432
56
2
Conjugate
This Retinoblastoma 1 antibody is un-conjugated
22
20
20
15
13
13
9
9
7
7
7
7
7
7
7
Application
Immunohistochemistry (IHC)
284
208
170
80
66
60
45
20
10
8
7
6
5
5
2
2
2
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Rb around the phosphorylation site of serine 807 (Y-I-SP-P-L).
Specificity Rb (phospho-Ser807) antibody detects endogenous levels of Rb only when phosphorylated at serine 807.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Rb (RB1 Antibody Abstract)
Research Area Cancer, Transcription Factors
Pathways Cell Division Cycle
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Roesch, Becker, Meyer, Hafner, Wild, Landthaler, Vogt: "Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 4, pp. 565-72, 2005

Chadee, Kyriakis: "MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation." in: Nature cell biology, Vol. 6, Issue 8, pp. 770-6, 2004

Knudsen, Wang: "Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites." in: The Journal of biological chemistry, Vol. 271, Issue 14, pp. 8313-20, 1996

Background publications Knudsen, Wang: "Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5771-83, 1997