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SAPK, JNK (pThr183) antibody

Details for Product No. ABIN966992, Supplier: Log in to see
Antigen
Epitope
pThr183
8
5
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
27
21
21
Host
Rabbit
26
1
Application
Immunohistochemistry (IHC)
25
24
10
3
2
2
1
1
1
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human JNK2/3/SAPK around the phosphorylation site of threonine 183 (M-M-TP-P-Y).
Specificity SAPK/JNK (phospho-Thr183) antibody detects endogenous levels of SAPK/JNK only when phosphorylated at threonine 183.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name SAPK/JNK
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Matsuyoshi, Shimada, Nakamura, Ishida, Konishi: "FADD phosphorylation is critical for cell cycle regulation in breast cancer cells." in: British journal of cancer, Vol. 94, Issue 4, pp. 532-9, 2006 (PubMed).

Ouwens, de Ruiter, van der Zon, Carter, Schouten, van der Burgt, Kooistra, Bos, Maassen, van Dam: "Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38." in: The EMBO journal, Vol. 21, Issue 14, pp. 3782-93, 2002 (PubMed).

Guan, Buckman, Springer, Morrison: "Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells." in: The Journal of biological chemistry, Vol. 274, Issue 51, pp. 36200-6, 2000 (PubMed).