Sirtuin 6 (SIRT6) (C-Term,pTyr526,pTyr527) antibody

Antigen: Sirtuin 6 (SIRT6)

Synonyms: Sir2l6, AI043036, 2810449N18Rik, SIR2L6, MGC114368, SIRT6

Binding Site: C-Term,pTyr526,pTyr527

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN967033

Additional Information

Alternative name: SIRT6

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6)

Description: SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) is included in class IV of the sirtuin family. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) contains 1 deacetylase sirtuin-type domain.
Synonyms: SIR2L6(SIR2-like protein 6)

Application Details

Research Area: Cancer

Restrictions: For Research Use only

Publications

Product: Frye: "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins." in: Biochemical and biophysical research communications, Vol. 273, Issue 2, pp. 793-8, 2000 (PubMed).

Kanfi, Shalman, Peshti et al.: "Regulation of SIRT6 protein levels by nutrient availability." in: FEBS letters, Vol. 582, Issue 5, pp. 543-8, 2008 (PubMed).

Michishita, McCord, Berber et al.: "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin." in: Nature, Vol. 452, Issue 7186, pp. 492-6, 2008 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Kawahara, Michishita, Adler et al.: "SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span." in: Cell, Vol. 136, Issue 1, pp. 62-74, 2009 (PubMed).