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SMAD, Mothers Against DPP Homolog 1 (SMAD1) (C-Term) antibody

Details for Product No. ABIN967044, Supplier: Login to see
Antigen
  • MLP
  • Xmad1
  • Xsmad1
  • bsp1
  • jv4-1
  • jv41
  • madh1
  • madr1
  • smad-1
  • MADH1
  • fb39h09
  • wu:fb39h09
  • wu:fb97e04
  • 2/23
  • CG12399
  • Dmel\\CG12399
  • E(zen)2
  • En(vvl)
  • MAD
  • Mat
  • P-Mad
  • P-mad
  • PMad
  • Smad
  • Smad1
  • apg
  • c28
  • dMAD
  • dMad
  • l(2)K00237
  • l(2)k00237
  • mad
  • p-Mad
  • pMAD
  • pMad
  • pSmad
  • BSP-1
  • BSP1
  • JV4-1
  • JV41
  • MADR1
  • AI528653
  • Madh1
  • Madr1
  • Mlp1
  • MusMLP
  • smad1
  • xmad
Epitope
C-Term
50
29
27
18
16
16
12
9
8
7
6
6
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
296
147
132
15
11
10
9
7
6
5
4
4
4
4
4
4
4
4
3
2
2
2
1
1
1
Host
Rabbit
274
39
2
Clonality
Polyclonal
Conjugate
Un-conjugated
9
8
5
3
3
3
3
3
3
3
3
3
2
2
2
Application
Western Blotting (WB)
258
126
71
41
33
33
18
11
6
5
5
3
2
2
1
1
1
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human Smad 1,2,3,5, identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 1 (SMAD1) detection. Tested with WB in Human, Mouse, Rat.
Alternative Name Mothers against decapentaplegic homolog 1(MAD homolog 1/Mothers against DPP homolog 1) (SMAD1 Antibody Abstract)
Background SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
Pathways
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Zhu, Kavsak, Abdollah et al.: "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation." in: Nature, Vol. 400, Issue 6745, pp. 687-93, 1999 (PubMed).