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Snail Family Zinc Finger 2 (SNAI2) antibody

Details for Product No. ABIN967056, Supplier: Log in to see
Antigen
Reactivity
Human
116
40
26
Host
Mouse
60
56
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
92
35
21
19
17
15
11
5
2
1
1
1
1
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Immunogen Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Clone 2H5
Isotype IgG1
Purification Ascitic fluid
Alternative Name SNAI2
Background This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in alpha-irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Synonyms: SLUG, WS2D, SLUGH1, MGC10182, SNAI2
Molecular Weight 30kDa
Gene ID 6591
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Saegusa, Hashimura, Kuwata et al.: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009 (PubMed).

Medici, Hay, Olsen: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, 2008 (PubMed).

Background publications Ye, Xiao, Wang et al.: "ERalpha suppresses slug expression directly by transcriptional repression." in: The Biochemical journal, Vol. 416, Issue 2, pp. 179-87, 2008 (PubMed).