SLUG antibody (C-Term)

Catalog No. ABIN967057

Product Details anti-SLUG Antibody

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLUG antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near C-terminal residues of human SNAI2

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-SLUG antibody (ABIN967057)

Larriba, Martín-Villar, García, Pereira, Peña, de Herreros, Bonilla, Muñoz: "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer." in: Carcinogenesis, Vol. 30, Issue 8, pp. 1459-68, (2009) (PubMed).

Wang, Wang, Chang, Wu, Chao, Kao, Yuan, Lin, Yang, Chan, Li, Hong, Yang: "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug." in: Nature cell biology, Vol. 11, Issue 6, pp. 694-704, (2009) (PubMed).

Saegusa, Hashimura, Kuwata, Okayasu: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).

Hemavathy, Guru, Harris, Chen, Ip: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, (2000) (PubMed).

Inukai, Inoue, Kurosawa, Goi, Shinjyo, Ozawa, Mao, Inaba, Look: "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein." in: Molecular cell, Vol. 4, Issue 3, pp. 343-52, (1999) (PubMed).

Target Details for SLUG

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Alternative Name: SNAI2 (SNAI2 Products)

Synonyms: Slug antibody, Slugh antibody, Snail2 antibody, snail family transcriptional repressor 2 antibody, snail family zinc finger 2 antibody, Snai2 antibody

Background: SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The SNAI2 protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress Ecadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this SNAI2 gene may be associated with sporatic cases of neural tube defects.
Synonyms: MGC10182, SLUG, SLUGH1, WS2D