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MAPT antibody (Microtubule-Associated Protein tau) (pSer214)

Details for Product anti-MAPT Antibody No. ABIN967143, Supplier: Log in to see
Antigen
  • tau
  • xtp
  • MAPT
  • AI426939
  • AI551861
  • AW457082
  • CK1epsilon
  • CKIe
  • KC1epsilon
  • DDPAC
  • FTDP-17
  • MAPTL
  • MSTD
  • MTBT1
  • MTBT2
  • PPND
  • TAU
  • AI413597
  • AW045860
  • Mtapt
  • Tau
  • PHF-tau
  • RNPTAU
  • pTau
  • microtubule-associated protein tau
  • Microtubule-associated protein tau
  • casein kinase 1, epsilon
  • mapt
  • MAPT
  • AaeL_AAEL015538
  • AaeL_AAEL012206
  • CpipJ_CPIJ013260
  • tau
  • Csnk1e
  • Mapt
Alternatives
anti-Human MAPT antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)
Epitope
pSer214
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
1026
669
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Host
Rabbit
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Conjugate
This MAPT antibody is un-conjugated
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Application
Immunohistochemistry (IHC)
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Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 214 (T-P-SP-L-P).
Specificity Tau (phospho-Ser214) antibody detects endogenous levels of Tau only when phosphorylated at serine 214.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Tau (MAPT Antibody Abstract)
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics, M Phase
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Smet, Wieruszeski, Buée, Landrieu, Lippens: "Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein." in: FEBS letters, Vol. 579, Issue 19, pp. 4159-64, 2005 (PubMed).

Product cited in: Puig, Rey, Ferrer: "Individual and regional variations of phospho-tau species in progressive supranuclear palsy." in: Acta neuropathologica, Vol. 110, Issue 3, pp. 261-8, 2005 (PubMed).

Götz, Chen, van Dorpe, Nitsch: "Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils." in: Science (New York, N.Y.), Vol. 293, Issue 5534, pp. 1491-5, 2001 (PubMed).

Illenberger, Zheng-Fischhöfer, Preuss, Stamer, Baumann, Trinczek, Biernat, Godemann, Mandelkow, Mandelkow: "The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease." in: Molecular biology of the cell, Vol. 9, Issue 6, pp. 1495-512, 1998 (PubMed).