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Microtubule-Associated Protein tau (MAPT) (pSer214) antibody

Details for Product No. ABIN967143
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Antigen
Synonyms tau, xtp, MAPT, AI426939, AI551861, AW457082, CK1epsilon, CKIe, KC1epsilon, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, PHF-tau, RNPTAU, pTau
Epitope
pSer214
(44), (33), (33), (30), (30), (30), (30), (26), (25), (25), (25), (25), (24), (23), (18), (13), (12), (11), (11), (11), (11), (10), (10), (10), (9), (9), (9), (8), (8), (8), (8), (8), (7), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(858), (451), (424), (43), (8), (6), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(797), (87), (10), (8), (1)
Conjugate
Un-conjugated
(9), (4), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC)
(792), (343), (238), (91), (76), (60), (31), (30), (16), (13), (13), (13), (9), (3), (1), (1), (1)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN967143
385.00 $
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 214 (T-P-SP-L-P).
Specificity Tau (phospho-Ser214) antibody detects endogenous levels of Tau only when phosphorylated at serine 214.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Tau
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Illenberger, Zheng-Fischhöfer, Preuss et al.: "The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease." in: Molecular biology of the cell, Vol. 9, Issue 6, pp. 1495-512, 1998 (PubMed).

Götz, Chen, van Dorpe et al.: "Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils." in: Science (New York, N.Y.), Vol. 293, Issue 5534, pp. 1491-5, 2001 (PubMed).

Puig, Rey, Ferrer: "Individual and regional variations of phospho-tau species in progressive supranuclear palsy." in: Acta neuropathologica, Vol. 110, Issue 3, pp. 261-8, 2005 (PubMed).

Smet, Wieruszeski, Buée et al.: "Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein." in: FEBS letters, Vol. 579, Issue 19, pp. 4159-64, 2005 (PubMed).

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