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Microtubule-Associated Protein tau (MAPT) (pSer214) antibody

Antigen

Microtubule-Associated Protein tau (MAPT)
Synonyms TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549, Tau, Mtapt, AI413597, AW045860, pTau, RNPTAU, MGC156663, tau, MGC134287, xtp, MAPT
Binding Site
Alternatives

pSer214
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
4 references available
Catalog no. ABIN967143
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name Tau
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 214 (T-P-SP-L-P).
Specificity Tau (phospho-Ser214) antibody detects endogenous levels of Tau only when phosphorylated at serine 214.

Application Details
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Application Notes WB: 1:500~1:1000.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Illenberger, Zheng-Fischhöfer, Preuss et al.: "The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease." in: Molecular biology of the cell, Vol. 9, Issue 6, pp. 1495-512, 1998 (PubMed).

Götz, Chen, van Dorpe et al.: "Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils." in: Science (New York, N.Y.), Vol. 293, Issue 5534, pp. 1491-5, 2001 (PubMed).

Puig, Rey, Ferrer: "Individual and regional variations of phospho-tau species in progressive supranuclear palsy." in: Acta neuropathologica, Vol. 110, Issue 3, pp. 261-8, 2005 (PubMed).

Smet, Wieruszeski, Buée et al.: "Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein." in: FEBS letters, Vol. 579, Issue 19, pp. 4159-64, 2005 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Microtubule-Associated Protein tau (MAPT)", type "Antibodies"
Hosts Rabbit (348), Mouse (65), Goat (8), Chicken (4)
Reactivities Human (385), Rat (Rattus) (169), Mouse (Murine) (149), Cow (Bovine) (25), Chicken (2), Cat (Feline) (1), Dog (Canine) (1), Sheep (Ovine) (1)
Applications Western Blotting (WB) (368), ELISA (122), Immunohistochemistry (IHC) (84), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (60), Immunofluorescence (IF) (44), Immunoprecipitation (IP) (22), Dot Blot (Dot) (14), Cellular Assay (CA) (13), Immunoassay (IA) (13), Immunostaining (ISt) (13), Enzyme Immunoassay (EIA) (9), Immunocytochemistry (ICC) (8), Immunohistochemistry (Fixed) (IHC (fx)) (3), Flow Cytometry (FACS) (2), To be determined by user (TBD) (1)
Conjugates Biotin (6), FITC (1)
Epitopes pThr231 (16), pSer396 (15), pThr181 (15), pSer262 (14), pThr205 (13), pSer356 (12), N-Term (11), pSer214 (11), pSer235 (11), pSer404 (11), pThr212 (11), Internal Region (10), pSer422 (9), C-Term (8), pSer199 (5), Ser262 (4), Ser356 (4), Ser404 (4), Ser422 (4), Thr181 (4), pSer416 (4), pThr217 (4), Ser214 (3), Ser235 (3), Ser396 (3), Thr231 (3), pSer400 (3), pSer409 (3), pSer720 (3), AA 1-16 (2), Ser202 (2), Thr205 (2), Thr212 (2), pSer198 (2), pSer202 (2), 421/422 (1), AA 240-450 (1), Center (1), Isoform 13 (1), N-Term,AA 1-16 (1), Ser198, Ser199, Ser202, Thr205 (1), Ser396, Ser400, Ser404 (1), Ser400 (1), Ser409 (1), Ser720 (1), Thr212, Ser214, Thr217 (1), Thr217 (1), Transcript Variant 4 (1), pSer199, pSer202 (1), pSer199,pSer202 (1), pSer519 (1), pThr404 (1), pThr534 (1), pan (1)