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MAPT antibody (Microtubule-Associated Protein tau) (pSer235)

Details for Product anti-MAPT Antibody No. ABIN967144, Supplier: Log in to see
Antigen
  • AI413597
  • AI426939
  • AI551861
  • AW045860
  • AW457082
  • CK1epsilon
  • CKIe
  • DDPAC
  • FTDP-17
  • KC1epsilon
  • MAPT
  • MAPTL
  • MSTD
  • Mtapt
  • MTBT1
  • MTBT2
  • PHF-tau
  • PPND
  • pTau
  • RNPTAU
  • tau
  • Tau
  • TAU
  • xtp
Alternatives
anti-Human MAPT antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)
Epitope
pSer235
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Conjugate
This MAPT antibody is un-conjugated
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Application
Immunohistochemistry (IHC)
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Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 235 (P-K-SP-P-S).
Specificity Tau (phospho-Ser235) antibody detects endogenous levels of Tau only when phosphorylated at serine 235.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Tau (MAPT Antibody Abstract)
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Lalonde, Kim, Fukuchi: "Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice." in: Neuroscience letters, Vol. 369, Issue 2, pp. 156-61, 2004

Liu, Iqbal, Grundke-Iqbal, Gong: "Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta." in: FEBS letters, Vol. 530, Issue 1-3, pp. 209-14, 2002

Sengupta, Kabat, Novak, Wu, Grundke-Iqbal, Iqbal: "Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules." in: Archives of biochemistry and biophysics, Vol. 357, Issue 2, pp. 299-309, 1998

Background publications Alonso, Mederlyova, Novak, Grundke-Iqbal, Iqbal: "Promotion of hyperphosphorylation by frontotemporal dementia tau mutations." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34873-81, 2004

Kyriakis, Banerjee, Nikolakaki, Dai, Rubie, Ahmad, Avruch, Woodgett: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994