anti-MAPT antibody (Microtubule-Associated Protein tau) (pSer235)

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Antigen
Synonyms tau, xtp, MAPT, AI426939, AI551861, AW457082, CK1epsilon, CKIe, KC1epsilon, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, PHF-tau, RNPTAU, pTau
Alternatives
Epitope
pSer235
(65), (42), (41), (40), (37), (35), (34), (33), (32), (31), (30), (29), (27), (25), (21), (17), (14), (14), (14), (14), (13), (13), (12), (12), (11), (11), (11), (11), (11), (10), (10), (10), (9), (8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(1092), (493), (451), (65), (13), (12), (8), (8), (6), (4), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(1028), (112), (15), (12)
Conjugate
This MAPT antibody is un-conjugated
(26), (8), (7), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(995), (426), (334), (104), (94), (74), (46), (22), (15), (15), (12), (12), (12), (11), (6), (6), (4), (2), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 235 (P-K-SP-P-S).
Specificity Tau (phospho-Ser235) antibody detects endogenous levels of Tau only when phosphorylated at serine 235.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Tau (MAPT Antibody Abstract)
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Lalonde, Kim, Fukuchi: "Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice." in: Neuroscience letters, Vol. 369, Issue 2, pp. 156-61, 2004 (PubMed).

Liu, Iqbal, Grundke-Iqbal et al.: "Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta." in: FEBS letters, Vol. 530, Issue 1-3, pp. 209-14, 2002 (PubMed).

Sengupta, Kabat, Novak et al.: "Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules." in: Archives of biochemistry and biophysics, Vol. 357, Issue 2, pp. 299-309, 1998 (PubMed).

Background publications Alonso, Mederlyova, Novak et al.: "Promotion of hyperphosphorylation by frontotemporal dementia tau mutations." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34873-81, 2004 (PubMed).

Kyriakis, Banerjee, Nikolakaki et al.: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994 (PubMed).

Catalog No. ABIN967144
$398.75
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