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Details for Product No. ABIN967144

tau (pSer235) antibody

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Antigen
Epitope
»Alternatives pSer235
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN967144
Quantity 100 µg
Price
385.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 5 to 7 Business Days
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 235 (P-K-SP-P-S).
Specificity Tau (phospho-Ser235) antibody detects endogenous levels of Tau only when phosphorylated at serine 235.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Kyriakis, Banerjee, Nikolakaki et al.: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994 (PubMed).

Sengupta, Kabat, Novak et al.: "Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules." in: Archives of biochemistry and biophysics, Vol. 357, Issue 2, pp. 299-309, 1998 (PubMed).

Liu, Iqbal, Grundke-Iqbal et al.: "Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta." in: FEBS letters, Vol. 530, Issue 1-3, pp. 209-14, 2002 (PubMed).

Alonso, Mederlyova, Novak et al.: "Promotion of hyperphosphorylation by frontotemporal dementia tau mutations." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34873-81, 2004 (PubMed).

Lalonde, Kim, Fukuchi: "Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice." in: Neuroscience letters, Vol. 369, Issue 2, pp. 156-61, 2004 (PubMed).

Alternatives for antigen "tau", type "Antibodies"
Hosts (294), (28), (5), (1)
Reactivities (316), (252), (243), (15), (3), (2), (2), (2), (1), (1), (1), (1)
Applications (287), (161), (69), (20), (13), (13), (13), (13), (12), (9), (9), (7), (1), (1), (1), (1)
Conjugates (2), (1), (1), (1)
Epitopes (25), (16), (14), (12), (12), (12), (12), (11), (10), (10), (10), (9), (9), (8), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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