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MAPT antibody (Microtubule-Associated Protein tau) (pSer396)

Details for Product anti-MAPT Antibody No. ABIN967146, Supplier: Login to see
Antigen
  • tau
  • xtp
  • MAPT
  • AI426939
  • AI551861
  • AW457082
  • CK1epsilon
  • CKIe
  • KC1epsilon
  • DDPAC
  • FTDP-17
  • MAPTL
  • MSTD
  • MTBT1
  • MTBT2
  • PPND
  • TAU
  • AI413597
  • AW045860
  • Mtapt
  • Tau
  • PHF-tau
  • RNPTAU
  • pTau
Alternatives
anti-Human MAPT antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)
Epitope
pSer396
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
953
407
387
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9
5
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Host
Rabbit
904
105
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Conjugate
This MAPT antibody is un-conjugated
25
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5
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1
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Application
Immunohistochemistry (IHC)
854
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Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 396 (Y-K-SP-P-V).
Specificity Tau (phospho-Ser396) antibody detects endogenous levels of Tau only when phosphorylated at serine396.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Tau (MAPT Antibody Abstract)
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: DeGiorgis, Jaffe, Moreira et al.: "Phosphoproteomic analysis of synaptosomes from human cerebral cortex." in: Journal of proteome research, Vol. 4, Issue 2, pp. 306-15, 2005 (PubMed).

Background publications Puig, Rey, Ferrer: "Individual and regional variations of phospho-tau species in progressive supranuclear palsy." in: Acta neuropathologica, Vol. 110, Issue 3, pp. 261-8, 2005 (PubMed).

Alonso, Mederlyova, Novak et al.: "Promotion of hyperphosphorylation by frontotemporal dementia tau mutations." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34873-81, 2004 (PubMed).

Kyriakis, Banerjee, Nikolakaki et al.: "The stress-activated protein kinase subfamily of c-Jun kinases." in: Nature, Vol. 369, Issue 6476, pp. 156-60, 1994 (PubMed).