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MAPT antibody (Microtubule-Associated Protein tau) (pSer404)

Details for Product anti-MAPT Antibody No. ABIN967147, Supplier: Log in to see
Antigen
  • AI413597
  • AI426939
  • AI551861
  • AW045860
  • AW457082
  • CK1epsilon
  • CKIe
  • DDPAC
  • FTDP-17
  • KC1epsilon
  • MAPT
  • MAPTL
  • MSTD
  • Mtapt
  • MTBT1
  • MTBT2
  • PHF-tau
  • PPND
  • pTau
  • RNPTAU
  • tau
  • Tau
  • TAU
  • xtp
Alternatives
anti-Human MAPT antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)
Epitope
pSer404
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
966
466
444
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12
9
5
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Host
Rabbit
920
98
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Conjugate
This MAPT antibody is un-conjugated
23
8
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5
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1
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Application
Immunohistochemistry (IHC)
862
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Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 404 (D-T-SP-P-R).
Specificity Tau (phospho-Ser404) antibody detects endogenous levels of Tau only when phosphorylated at serine404.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Tau (MAPT Antibody Abstract)
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Gustin, Ozes, Akca, Pincheira, Mayo, Li, Guzman, Korgaonkar, Donner: "Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1615-20, 2004

Li, Yin, Kuret: "Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules." in: The Journal of biological chemistry, Vol. 279, Issue 16, pp. 15938-45, 2004

Noble, Olm, Takata, Casey, Mary, Meyerson, Gaynor, LaFrancois, Wang, Kondo, Davies, Burns, Veeranna, Nixon, Dickson, Matsuoka, Ahlijanian, Lau, Duff: "Cdk5 is a key factor in tau aggregation and tangle formation in vivo." in: Neuron, Vol. 38, Issue 4, pp. 555-65, 2003

Background publications Giasson, Sampathu, Wilson, Vogelsberg-Ragaglia, Mushynski, Lee: "The environmental toxin arsenite induces tau hyperphosphorylation." in: Biochemistry, Vol. 41, Issue 51, pp. 15376-87, 2002

Andreadis, Brown, Kosik: "Structure and novel exons of the human tau gene." in: Biochemistry, Vol. 31, Issue 43, pp. 10626-33, 1992

Lee, Neve, Kosik: "The microtubule binding domain of tau protein." in: Neuron, Vol. 2, Issue 6, pp. 1615-24, 1990