Microtubule-Associated Protein tau (MAPT) (pSer404) antibody

Details for Product No. ABIN967147
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Antigen
Synonyms DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, Tau, Mtapt, AI413597, AW045860, RNPTAU, pTau, tau, xtp, MAPT
Epitope
pSer404
(38), (33), (32), (31), (30), (29), (29), (27), (25), (25), (24), (24), (23), (23), (18), (13), (11), (11), (10), (9), (9), (9), (9), (9), (8), (8), (8), (8), (7), (7), (7), (7), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(816), (449), (422), (41), (9), (7), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(759), (89), (10), (7), (1)
Conjugate
Un-conjugated
(7), (2), (1), (1)
Application
Immunohistochemistry (IHC)
(756), (298), (216), (92), (70), (49), (32), (30), (14), (13), (13), (13), (9), (5), (2), (1), (1), (1)
Pubmed 6 references available
Catalog no. ABIN967147
Quantity 100 µg
Price
385.00 $   Plus shipping costs $45.00
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Tau around the phosphorylation site of serine 404 (D-T-SP-P-R).
Specificity Tau (phospho-Ser404) antibody detects endogenous levels of Tau only when phosphorylated at serine404.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Tau
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Andreadis, Brown, Kosik: "Structure and novel exons of the human tau gene." in: Biochemistry, Vol. 31, Issue 43, pp. 10626-33, 1992 (PubMed).

Lee, Neve, Kosik: "The microtubule binding domain of tau protein." in: Neuron, Vol. 2, Issue 6, pp. 1615-24, 1990 (PubMed).

Giasson, Sampathu, Wilson et al.: "The environmental toxin arsenite induces tau hyperphosphorylation." in: Biochemistry, Vol. 41, Issue 51, pp. 15376-87, 2002 (PubMed).

Noble, Olm, Takata et al.: "Cdk5 is a key factor in tau aggregation and tangle formation in vivo." in: Neuron, Vol. 38, Issue 4, pp. 555-65, 2003 (PubMed).

Gustin, Ozes, Akca et al.: "Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1615-20, 2004 (PubMed).

Li, Yin, Kuret: "Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules." in: The Journal of biological chemistry, Vol. 279, Issue 16, pp. 15938-45, 2004 (PubMed).

Hosts (759), (89), (10), (7), (1)
Reactivities (816), (449), (422), (41), (9), (7), (3), (2), (2), (1), (1), (1)
Applications (756), (298), (216), (92), (70), (49), (32), (30), (14), (13), (13), (13), (9), (5), (2), (1), (1), (1)
Conjugates (7), (2), (1), (1)
Epitopes (38), (33), (32), (31), (30), (29), (29), (27), (25), (25), (24), (24), (23), (23), (18), (13), (11), (11), (10), (9), (9), (9), (9), (9), (8), (8), (8), (8), (7), (7), (7), (7), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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