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TLR9 antibody (Toll-Like Receptor 9) (C-Term)

Details for Product anti-TLR9 Antibody No. ABIN967189, Supplier: Log in to see
Antigen
  • CD289
Alternatives
anti-Mouse (Murine) TLR9 antibody for Immunohistochemistry (Frozen Sections)
Epitope
C-Term
48
35
18
15
15
10
8
7
6
5
5
5
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
206
88
25
4
3
3
3
1
1
1
1
1
Host
Rabbit
125
82
23
16
3
2
Clonality
Polyclonal
Conjugate
This TLR9 antibody is un-conjugated
25
23
14
7
6
4
Application
Immunohistochemistry (IHC)
191
102
84
75
54
35
16
16
7
7
6
4
3
3
3
2
2
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse Tlr9 (Toll-like receptor 9)
Alternative Name Tlr9 (TLR9 Antibody Abstract)
Background Tlr9 (Toll-like receptor 9) participates in the innate immune response to microbial agents. Tlr9 (Toll-like receptor 9) detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Tlr9 (Toll-like receptor 9) plays a role in defense against sytemic mouse cytomegalovirus infection. Tlr9 (Toll-like receptor 9) binds MYD88 via their respective TIR domains and interacts with CNPY3. Tlr9 (Toll-like receptor 9) belongs to the Toll-like receptor family and contains 26 LRR (leucine-rich) repeats and 1 TIR domain.
Pathways TLR Signaling
Restrictions For Research Use only
Product cited in: Kiyokawa, Akashi-Takamura, Shibata, Matsumoto, Nishitani, Kuroki, Seto, Miyake: "A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors." in: International immunology, Vol. 20, Issue 11, pp. 1407-15, 2008

Tabeta, Georgel, Janssen, Du, Hoebe, Crozat, Mudd, Shamel, Sovath, Goode, Alexopoulou, Flavell, Beutler: "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3516-21, 2004

Chuang, Lee, Kline, Mathison, Ulevitch: "Toll-like receptor 9 mediates CpG-DNA signaling." in: Journal of leukocyte biology, Vol. 71, Issue 3, pp. 538-44, 2002

Bauer, Kirschning, Häcker, Redecke, Hausmann, Akira, Wagner, Lipford: "Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9237-42, 2001

Background publications Hemmi, Takeuchi, Kawai, Kaisho, Sato, Sanjo, Matsumoto, Hoshino, Wagner, Takeda, Akira: "A Toll-like receptor recognizes bacterial DNA." in: Nature, Vol. 408, Issue 6813, pp. 740-5, 2000