TLR9 antibody (Toll-Like Receptor 9) (N-Term)

Details for Product anti-TLR9 Antibody No. ABIN967190, Supplier: Log in to see
Antigen
  • CD289
  • toll-like receptor 9
  • TLR9
  • Tlr9
Alternatives
anti-Mouse (Murine) TLR9 antibody for Cytometry by Time of Flight
Epitope
N-Term
40
32
16
13
13
11
8
8
7
6
6
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
260
163
58
39
25
22
8
6
4
2
2
2
2
2
1
1
1
Host
Rabbit
138
121
53
14
4
3
Clonality
Polyclonal
Conjugate
This TLR9 antibody is un-conjugated
28
27
19
6
6
6
5
5
5
5
4
3
3
3
3
3
3
3
3
3
2
1
1
Application
Immunohistochemistry (IHC)
241
178
105
102
89
41
37
36
15
7
6
5
5
3
3
3
3
3
2
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse Tlr9 (Toll-like receptor 9)
Alternative Name Tlr9 (TLR9 Antibody Abstract)
Background Tlr9 (Toll-like receptor 9) participates in the innate immune response to microbial agents. Tlr9 (Toll-like receptor 9) detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Tlr9 (Toll-like receptor 9) plays a role in defense against sytemic mouse cytomegalovirus infection. Tlr9 (Toll-like receptor 9) binds MYD88 via their respective TIR domains and interacts with CNPY3. Tlr9 (Toll-like receptor 9) belongs to the Toll-like receptor family and contains 26 LRR (leucine-rich) repeats and 1 TIR domain.
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
Restrictions For Research Use only
Product cited in: Kiyokawa, Akashi-Takamura, Shibata, Matsumoto, Nishitani, Kuroki, Seto, Miyake: "A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors." in: International immunology, Vol. 20, Issue 11, pp. 1407-15, 2008 (PubMed).

Tabeta, Georgel, Janssen, Du, Hoebe, Crozat, Mudd, Shamel, Sovath, Goode, Alexopoulou, Flavell, Beutler: "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 10, pp. 3516-21, 2004 (PubMed).

Chuang, Lee, Kline, Mathison, Ulevitch: "Toll-like receptor 9 mediates CpG-DNA signaling." in: Journal of leukocyte biology, Vol. 71, Issue 3, pp. 538-44, 2002 (PubMed).

Bauer, Kirschning, Häcker, Redecke, Hausmann, Akira, Wagner, Lipford: "Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9237-42, 2001 (PubMed).

Background publications Hemmi, Takeuchi, Kawai, Kaisho, Sato, Sanjo, Matsumoto, Hoshino, Wagner, Takeda, Akira: "A Toll-like receptor recognizes bacterial DNA." in: Nature, Vol. 408, Issue 6813, pp. 740-5, 2000 (PubMed).