Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody

Antigen: Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1)

Synonyms: MTC, TRK, TRK1, TRKA, p140-TrkA, DKFZp781I14186, Tkr, trk, TrkA, C80751, trka, Trk, NTRK1, trkA, CTRKA

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN967209

Additional Information

Alternative name: Trk-A

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human Trk-A, identical to the related rat and mouse sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: Trk A (Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor (NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF4(Neurotrophin-4) and BDNF, and NTF3(Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA(NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform(s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes.1 Indo et al. (1996) concluded that defects in TRKA cause CIPA (Congenital insensitivity to pain with anhidrosis ) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect(s) of the nervous system.2

Application Details

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Restrictions: For Research Use only

Publications

Product: Indo, Tsuruta, Hayashida et al.: "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis." in: Nature genetics, Vol. 13, Issue 4, pp. 485-8, 1996 (PubMed).

Bonini, Lambiase, Bonini et al.: "Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10955-60, 1996 (PubMed).

Lambiase, Merlo, Mollinari et al.: "Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16795-800, 2005 (PubMed).