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TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (Middle Region)

Details for Product anti-NTRK1 Antibody No. ABIN967209, Supplier: Log in to see
Antigen
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
Alternatives
anti-Human TRKA antibody for Immunoprecipitation
Epitope
Middle Region
50
22
22
18
18
16
16
15
15
15
13
13
13
12
12
11
10
10
9
9
7
7
6
6
6
5
5
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
407
247
200
2
2
Host
Rabbit
373
59
4
4
2
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
16
15
15
11
8
8
8
8
8
7
7
7
7
7
7
7
6
2
2
2
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
259
153
93
88
64
52
51
39
20
9
5
5
4
2
Options
Supplier
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Immunogen A synthetic peptide corresponding to a sequence in the middle region of human NTRK1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor ( NTRK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Alternative Name High affinity nerve growth factor receptor (NTRK1) (NTRK1 Antibody Abstract)
Background Trk A (Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor (NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF4 (Neurotrophin-4) and BDNF, and NTF3 (Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA (NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform (s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes. Indo et al. (1996) concluded that defects in TRKA cause CIPA (Congenital insensitivity to pain with anhidrosis ) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect (s) of the nervous system.
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Lambiase, Merlo, Mollinari, Bonini, Rinaldi, D Amato, Micera, Coassin, Rama, Bonini, Garaci: "Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16795-800, 2005 (PubMed).

Indo, Tsuruta, Hayashida, Karim, Ohta, Kawano, Mitsubuchi, Tonoki, Awaya, Matsuda: "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis." in: Nature genetics, Vol. 13, Issue 4, pp. 485-8, 1996 (PubMed).

Bonini, Lambiase, Bonini, Angelucci, Magrini, Manni, Aloe: "Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10955-60, 1996 (PubMed).