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TRPV1 antibody (Middle Region)

TRPV1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN967211
  • Target See all TRPV1 Antibodies
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    Binding Specificity
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 38
    • 28
    • 24
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 53
    • 6
    • 2
    • 2
    Rabbit
    Clonality
    • 58
    • 5
    Polyclonal
    Conjugate
    • 40
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This TRPV1 antibody is un-conjugated
    Application
    • 32
    • 24
    • 13
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Transient receptor potential cation channel subfamily V member 1 ( TRPV1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human TRPV1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
    Isotype
    IgG
    Top Product
    Discover our top product TRPV1 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Sodium azide, Thimerosal (Merthiolate)
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Cui, Honore, Zhong, Gauvin, Mikusa, Hernandez, Chandran, Gomtsyan, Brown, Bayburt, Marsh, Bianchi, McDonald, Niforatos, Neelands, Moreland, Decker, Lee, Sullivan, Faltynek: "TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 37, pp. 9385-93, (2006) (PubMed).

    Birder, Nakamura, Kiss, Nealen, Barrick, Kanai, Wang, Ruiz, De Groat, Apodaca, Watkins, Caterina: "Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1." in: Nature neuroscience, Vol. 5, Issue 9, pp. 856-60, (2002) (PubMed).

    Xue, Yu, Trilk, Jong, Schumacher: "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants." in: Genomics, Vol. 76, Issue 1-3, pp. 14-20, (2001) (PubMed).

    Eisenberg, Gresalfi, Riccio, McLaughlin: "Adsorption of monovalent cations to bilayer membranes containing negative phospholipids." in: Biochemistry, Vol. 18, Issue 23, pp. 5213-23, (1980) (PubMed).

  • Target
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    Alternative Name
    Transient receptor potential cation channel subfamily V member 1 (TRPV1) (TRPV1 Products)
    Synonyms
    si:dkey-9e15.2 antibody, VR.5'sv antibody, Vr1 antibody, Vr1l1 antibody, VR1 antibody, OTRPC1 antibody, TRPV1alpha antibody, TRPV1beta antibody, VR-1 antibody, transient receptor potential cation channel, subfamily V, member 1 antibody, transient receptor potential cation channel subfamily V member 1 antibody, trpv1 antibody, Trpv1 antibody, TRPV1 antibody
    Background
    The transient receptor potential cation channel, subfamily V, member 1 (TRPV1), also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1 (also called Vanilloid receptor type 1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, TRPV1 is also expressed in the CNS. Cui M et al. (2006) demonstrate that TRPV1 receptors in the CNS play an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And TRPV1 also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.
    Pathways
    Dicarboxylic Acid Transport
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