anti-TYRO3 antibody (TYRO3 Protein Tyrosine Kinase)

Details for Product anti-TYRO3 Antibody No. ABIN967221
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Antigen
Synonyms TYRO3, brt, byk, dtk, rse, sky, tif, Xksy, MGC145734, DKFZp469I0432, LOC100231598, BYK, Dtk, RSE, Sky, Tif, Brt, REK, ksy, xksy, AI323366, Etk-2, Rse
Reactivity
Human
(124), (26), (16), (1)
Host
(81), (44), (1)
Clonality
Monoclonal
Conjugate
This TYRO3 antibody is un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), ELISA
(99), (49), (36), (32), (24), (16), (12), (9), (7), (5), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Isotype IgG1
Specificity Ni-NTA purified truncated recombinant TYRO3 expressed in E. Coli strain BL21 (DE3)
Purification Crude ascites.
Alternative Name TYRO3 (TYRO3 Antibody Abstract)
Background Tyrosine-protein kinase (TYRO3) belongs to the Tyr protein kinase family (AXL/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl). Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
Gene ID 7301
Research Area Signaling, Tyrosine Kinases
Application Notes Western Blot: 1: 500- 1: 2,000
IF: 1:50- 1:200
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Biesecker, Giannola, Emerson: "Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explain differences in 5' cDNA sequences." in: Oncogene, Vol. 10, Issue 11, pp. 2239-42, 1995 (PubMed).

Janssen, Schulz, Steenvoorden et al.: "A novel putative tyrosine kinase receptor with oncogenic potential." in: Oncogene, Vol. 6, Issue 11, pp. 2113-20, 1991 (PubMed).

Schlessinger, Ullrich: "Growth factor signaling by receptor tyrosine kinases." in: Neuron, Vol. 9, Issue 3, pp. 383-91, 1992 (PubMed).

Validation Images
Catalog No. ABIN967221
440.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
440.00 $

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