TYRO3 antibody (Extracellular)

Catalog No. ABIN967224

Product Details anti-TYRO3 Antibody

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Binding Specificity: Extracellular

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TYRO3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human TYRO3 fused with hIgGFc tag expressed in HEK293 cell line.

Clone: 10E11

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for TYRO3

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Alternative Name: TYRO3 (TYRO3 Products)

Synonyms: TYRO3 antibody, brt antibody, byk antibody, dtk antibody, rse antibody, sky antibody, tif antibody, Xksy antibody, MGC145734 antibody, DKFZp469I0432 antibody, LOC100231598 antibody, BYK antibody, Dtk antibody, RSE antibody, Sky antibody, Tif antibody, Brt antibody, REK antibody, ksy antibody, xksy antibody, AI323366 antibody, Etk-2 antibody, Rse antibody, TYRO3 protein tyrosine kinase antibody, TYRO3 protein tyrosine kinase L homeolog antibody, TYRO3 protein tyrosine kinase 3 antibody, TYRO3 antibody, tyro3 antibody, Tyro3 antibody, tyro3.L antibody

Background: TYRO3: Tyrosine-protein kinase, also known as BYK, Brt, Dtk, Sky. Entrez Protein: NP_006284. It belongs to the Tyr protein kinase family (AXL/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl). Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
Synonyms: BYK, Brt, Dtk, RSE, Sky, Tif

Molecular Weight: 96.9kDa

Gene ID: 7301

Pathways: RTK Signaling